Navigation Links
NovaDel Announces Positive Data from Two Studies Comparing Zolpidem,Oral Spray to Ambien Tablets

In this analysis, time to reach therapeutic drug concentration levels of 20 ng/ml was measured for healthy volunteers in the NVD003 study. This analysis yielded the following results:

-- 79% of subjects using the 10 mg zolpidem oral spray reached therapeutic levels at 15 minutes post-dosing while only 26% of subjects using 10 mg tablets reached therapeutic levels at that time point. The difference between these two rates is statistically significant (p less than 0.0001).

-- 65% of subjects using the 5 mg zolpidem oral spray reached therapeutic levels at 15 minutes post-dosing while only 19% of subjects in the tablet group reached therapeutic levels by 15 minutes. This result is statistically significant (p less than 0.0003) in favor of the oral spray group.

-- A cross analysis between 5 mg oral spray and 10 mg Ambien(R) tablets showed that subjects using 5 mg oral spray reached therapeutic levels significantly faster at 15 minutes post-dosing than those using 10 mg tablets. These results are statistically significant (p less than 0.0002).

Overall analysis of the number of subjects reaching therapeutic levels by 15 minutes post-dosing suggests the potential of faster induction of sleep at lower drug doses may be achieved by using oral sprays.

Additional PD Assessment: Change in DSST to Measure Sedation

Patients in both zolpidem oral spray studies performed the digital symbol substitution test (DSST). According to Dr. Tom Roth, Director of Sleep Medicine at Henry Ford Hospital in Detroit, "DSST measurements are a scientifically, well accepted surrogate for sedation and a significant reduction in DSST score may indicate earlier onset of therapeutic action for these drugs."

NovaDel's findings from its pharmacodynamic study using DSST yielded the following results for healthy volunteers in the NVD003 study:

-- Subjects using the 10 mg oral spray showed a nearly fourfold greater reduction of DSST score at 13 minutes
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
4. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
5. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
11. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
Post Your Comments:
(Date:12/24/2014)... , Dec. 23, 2014  Lockton Dunning Benefits, ... Lockton Companies, announced the addition of Vice President ... join Lockton Dunning,s Pharmacy Consulting team, Excelsior Solutions. ... relevant industry experience to the position.  Most recently, ... Sales at Diplomat Specialty Pharmacy, where she has ...
(Date:12/24/2014)...  Medical Science Liaisons play a large role in ... medical device industry and key stakeholders, the role of ... as the device industry relies on them to build ... benchmarking firm, Best Practices, LLC, one area where Medical ... by harnessing new technology to enable education. Online conferences ...
(Date:12/22/2014)... MEMPHIS, Tenn. , Dec. 22, 2014   ... only automated, no-touch UV disinfection robot, announced today that ... GSA Schedule contract through November 2019.   ... to rapidly engage all levels of government purchasers, including ... facilities, as well as Homeland Security contacts purchasing solutions ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... The Thompson Group of Companies announced today that ... a Hamilton Sundstrand Corporation business. AIT will be organized ... terms of the purchase were not disclosed. ... marketing of process analytical instruments including Analect FTIR, PIONIR ...
... Healthcare Diagnostics announces two new three-year agreements with Novation ... chemistry and microscopy systems, and for microbiology systems and ... VHA and University HealthSystem Consortium (UHC) member organizations and ... The members served by Novation have access to ...
Cached Medicine Technology:Thompson Group Acquires Hamilton Sundstrand's Applied Instrument Technologies 2Novation® Awards Siemens as Single Source for Urine Chemistry and Microbiology Systems and Tests 2
(Date:12/24/2014)... By Steven Reinberg ... -- New guidelines from the American Diabetes Association (ADA) call ... people with diabetes to help prevent heart disease. These ... College of Cardiology and American Heart Association, which also recommend ... for heart disease, including people with diabetes. "We agree ...
(Date:12/24/2014)... For chic ladies, new fashionable outfits are necessary when heading ... Wish List, Angeldress.co.uk has chosen some of their ... holiday wardrobe by launching a promotion on its cheap clothes ... of 80% off, like a cheap suit. , “All items ... wedding dresses are among the hottest items in the global ...
(Date:12/24/2014)... Dr. Svetlana Gomer, MGS Tewksbury Dental, MGE ... with US Marines on November 14, 2014 for the ... Toys for Tots Literacy Program. This year’s event ... and audio books for the Toys for Tots Literacy ... It represents another major strike in the battle being ...
(Date:12/24/2014)... NY (PRWEB) December 24, 2014 The ... with regards to the various market dynamics such as ... robot assisted arthroscopy, the wait time for U.S. sports ... sports medicine market, and the challenges faced by the ... http://www.researchmoz.us/global-sports-medicine-market-report-2014-edition-report.html , The report also provides an ...
(Date:12/24/2014)... 24, 2014 Verde Pointe Dental Associates 2014 ... "Last years homemade Christmas sweater lit up, but this ... 2014 winner is Tandy Wilson for the second year in ... says Kirk Kimmerling DDS. "She took pictures of the entire ... sweater." , "Every year I enjoy stopping by ...
Breaking Medicine News(10 mins):Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 2Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 3Health News:Angeldress.co.uk Starts Its Big Sales by Offering Various Kinds of Cheap Clothes and Fashion Accessories 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 3Health News:Sports Medicine Market Report 2014: Global Industry Analysis, Share, Size, Trends, Growth and Forecast report 2Health News:Verde Pointe Dental Associates Announces the 2014 Ugly Sweater Holiday Contest Winner 2
... you are a man that suffers from depression, erectile dysfunction, fatigue, poor ... NEW MAN (renewman.com) is advising men ages 35 and over to have ... is estimated that 4 out of 5 men age 40 have low ... ...
... inflammation, suggest heart-healthy diet , , SATURDAY, April 4 (HealthDay ... gum disease than are normal-weight people, a new study ... to determine the link between gum disease and cardiovascular ... at the Harvard School of Public Health. , To ...
... Serial entrepreneur, pioneer in wireless healthcare, bedside patient ... Corporation, a leading provider of wireless handheld ... hospitals, today announced that James M. Sweeney has ... )Mr. Sweeney has been founder and CEO of ...
... have an effect , , , FRIDAY, April 3 (HealthDay News) -- ... it,s not uncommon for people to get far less than the ... Sleep Disorders Center at Baylor Regional Medical Center in Texas offers ... , Control caffeine . The cycle of downing ...
... - The Westaim Corporation today announced that it ... maximize the value of the Company,s strong balance ... Westaim has entered into a management services agreement ... affiliate of Goodwood Inc., to manage the day-to-day ...
... following is a statement by Lois Aronstein AARP NY ... Speaker Silver for their leadership in recognizing the critical ... times. Several key services that are critical to ... money were preserved in the final state budget.When people ...
Cached Medicine News:Health News:Male Hormone Treatment Provider Announces Family Doctor Alert 2Health News:Male Hormone Treatment Provider Announces Family Doctor Alert 3Health News:Male Hormone Treatment Provider Announces Family Doctor Alert 4Health News:Obesity Boosts Gum Disease Risk 2Health News:Obesity Boosts Gum Disease Risk 3Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 2Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 3Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 4Health News:Trouble Sleeping? Try These Tips 2Health News:Westaim enters into Management Services Agreement 2Health News:Older New Yorkers Maintain Key Health and Community Services in New York State Budget 2
Cleveland Bone Cutter #5, 17cm, 6-3/4"...
Beuse Zygomatic Arch Awl with slightly curved tip....
Steroid-eluting, single-pass lead. CapSure VDD2 optimizes VDD therapy and offers easier handling, proven performance, and choice....
Steroid eluting pacemaker leads...
Medicine Products: