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News from the Battlefield of Metastatic Cancer: Epeius,Biotechnologies Draws the Sword of Targeted Gene Delivery (Rexin-G),from the Stone of Chemistry and Physics

SAN MARINO, Calif., June 04, 2007 /PRNewswire/ -- (SEND2PRESS NEWSWIRE) -- Epeius Biotechnologies Corporation today announced the publication of a historic landmark in medical oncology and a definitive benchmark in the emerging field of cancer gene therapy. The first clinical report of its kind, Le Morte du Tumour -- published in the June issue of the International Journal of Oncology, Vol.30, pp. 1297-1307 -- documents the histologic features of tumor destruction observed in chemo-resistant cancers following intravenous infusions of Rexin-G(TM), the world's first tumor-targeted genetic medicine for cancer therapy. In other words, this paper documents the unprecedented efficacy of targeted gene delivery in the tragic battlefield of metastatic cancer, where all other treatments have historically failed.

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Previously, Gordon et al. reported that intravenous infusions of Rexin-G, a pathotropic nanoparticle bearing a cyto-ablative construct, induced tumor regression, reduced tumor burden, and improved survival, while enhancing the overall quality-of-life of patients with otherwise intractable cancers (2006). In this new clinical paper, the authors describe the major histopathologic and radiologic features that are characteristic of solid tumors under the onslaught of Rexin-G administered as a single therapeutic agent. To further promote tumor eradication and enhance cancer survival, the potential of an auxiliary gene transfer strategy was explored, specifically intended to induce cancer auto-immunization. This immunization strategy uses Rexin-G in combination with Reximmune-C(TM) a tumor-targeted expression vector bearing a granulocyte macrophage colony stimulating factor (GM-CSF) gene. The intent of this two-step approach is to bring a complement of cells involved in humoral and cell-mediated immunity in close proximity to the immunizing tumor antigens in a concerted effort to assist in tumor eradication and to promote a cancer vaccination in situ. Fea
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