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Newly Published Data from Large Study Support Cardiovascular Safety,of Avandia (Rosiglitazone Maleate)

ge of slightly over a year.

The results demonstrate that:

• there was no difference in the overall incidence of heart attack and coronary revascularization with Avandia-containing therapies (1.75 events per 100 person-years) versus non-Avandia containing therapies (1.76 events per 100 person-years) (hazard ratio 0.93, 95% CI 0.80 – 1.10);

• there was no difference in the risk of either heart attack (hazard ratio 0.92, 95% CI 0.73 – 1.16) or coronary revascularization (hazard ratio 0.94, 95% CI 0.79 – 1.12) - with Avandia-containing therapies compared to non-Avandia containing therapies;

• there was no difference in the risk of the composite outcome with Avandia monotherapy compared to metformin monotherapy (hazard ratio 1.07, 95% CI: 0.85 – 1.34), and similarly with Avandia monotherapy compared to sulfonylurea monotherapy (hazard ratio 0.82, 95% CI: 0.67 – 1.02);

• there was no difference in the risk of composite outcome with Avandia in combination with insulin therapy compared to other oral antidiabetic agents in combination with insulin (hazard ratio 0.88, 95% CI: 0.59 – 1.32).

Avandia is an effective medicine that is an important treatment for millions of patients who are using it to manage their diabetes, a disease with potentially devastating consequences if left unmanaged.

Glossary of Terms:

Coronary revascularization - the process of restoring blood flow of oxygen to the heart via a surgical procedure to bypass blockages or obstructions in the coronary arteries

Cohort - a group within a given population followed over a period of time

CI (con
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