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Newly Published Data Demonstrates Superiority of Cipralex Over,Duloxetine for Acute Treatment of Depression

COPENHAGEN, Denmark, June 04, 2007 /PRNewswire/ --

- Cipralex Better Tolerated and at Least as Effective in Long-Term Treatment

H. Lundbeck A/S announces new study data published today in the journal Current Medical Research and Opinion, demonstrating that Cipralex(R) (escitalopram) was superior to duloxetine in the acute treatment of patients with major depressive disorder (MDD) and was at least as efficacious in long-term treatment(1). The study directly compared Cipralex(R) (an allosteric serotonin reuptake inhibitor - ASRI) to duloxetine (the most recently introduced serotonin and noradrenaline reuptake inhibitor - SNRI) and these findings support the growing body of evidence that Cipralex(R) offers important treatment advantages over SNRI antidepressants such as duloxetine(2-6).

Depression is a serious illness that results in significant disability and is associated with both increased morbidity and the risk of suicide(7). Affecting around 121 million people globally(8,) the World Health Organization lists depression as the leading cause of disability worldwide(8). At present, there is no simple universal treatment effective for all patients and it is therefore relevant that treatments are directly compared in order to provide clinicians with information on the efficacy and tolerability benefits of the currently available treatments.

"The study demonstrates that Cipralex(R) was superior to duloxetine during acute treatment and at least as effective in long-term treatment with the added benefit of significantly better tolerability," said Dr Alan Wade, lead investigator and medical director of CPS Research, Glasgow, Scotland. "Data that compares antidepressants in this way is an important tool for physicians and allows them to make informed decisions about the best treatments for their patients."

Important key findings from the study:

The 24-week study investigated t
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