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New Study Suggests no Significant Impairment in Middle-of-the-Night,Balance, Mobility or Memory in Older Adults Using Ramelteon

tory organ). The composite score of each individual sensory test characterizes the overall level of a person's performance.

Results found that compared to placebo, a significant decrease in SOT composite score was observed with zolpidem (P<0.001), but not with ramelteon (P=0.837). Additional results showed:

    * Significant increase in turn time and turn sway versus placebo was seen

      with zolpidem (P<0.001, both), but not with ramelteon (P=0.776, P=0.982,


      respectively).


    * Immediate memory recall declined significantly with zolpidem (P=0.002),

      but not with ramelteon (P=0.683).


    * Adverse events were reported in 13 patients with zolpidem and seven

      patients each during placebo and ramelteon treatment; none were noted as


      serious.

"This study contributes to the growing body of data showing that ramelteon is a safe option for older adults suffering from insomnia characterized by difficulty with sleep onset," said Zammit. "The trial will also help physicians better understand the unique and differentiating mechanism of action of ramelteon and its potential benefits when making appropriate prescribing decisions for their patients."

About Ramelteon

Ramelteon is indicated for the treatment of insomnia characterized by difficulty with sleep onset. Ramelteon can be prescribed for long-term use. Ramelteon is the first and only prescription sleep medication that has shown no evidence of abuse or dependence in clinical studies,* and has not been designated as a controlled substance. With the exception of ramelteon, all other prescription medications indicated for insomnia are classified as Schedule IV controlled substances by the U.S. Drug Enforcement Administration.

Ramelteon has a unique therapeutic mechanism of action that selectively targets two receptors located in the brain's suprachiasmatic nucleus (SCN). The SCN is known as the body's "master clock" because it regulates the sl
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