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New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes,Using Self-Adjusted Dosing Starting With Once-Daily Insulin,Treatment Levemir

Minimal Weight Change Reported Unlike What Is Commonly Seen In Insulin Therapy

CHICAGO, June 24, 2007 – Novo Nordisk today announced results of a new study that further demonstrated the safety and efficacy of insulin Levemir® (insulin detemir [rDNA origin] injection). Patients with Type 2 diabetes were able to adjust their own dosage of Levemir® and achieve improvements in blood sugar, comparable to dosing adjusted by their primary care physician. This improvement in A1c levels was observed with minimal weight change and without increases in rates of hypoglycemia. The data were presented at the 67th Scientific Sessions of the American Diabetes Association (ADA) in Chicago, Illinois.

“The study is a testament to the safety of Levemir®, as patients were able to adjust their basal insulin dose on their own and achieve the same level of glycemic control as when guided by their doctor, while reducing the risk of hypoglycemia” said Luigi Meneghini, MD, MBA, Associate Professor of Clinical Medicine and the Director of the Eleanor and Joseph Kosow Diabetes Treatment Center at the Diabetes Research Institute, Miami, FL. “Since having Type 2 diabetes requires a great deal of self-management, these findings will help empower patients to work more closely as partners with their physician to take control of their insulin treatment. The potential of improved self-management is made possible by insulin analogs like Levemir®, which provide effective basal insulin coverage, and, as shown in this study, the added benefit of minimal weight change.”

The new data were obtained from the insulin detemir 303 Algorithm tested in a Randomized Clinical Trial: The US PREDICTIVE™ 303 Trial (Predictable Results and Experience in Diabetes through Intensification and Control to Target: An International Variability Evaluation), which included 5,604 patients. The da
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