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New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder

- Data Presented at 2007 APA Meeting -

COLLEGEVILLE, Pa., May 21, 2007 /PRNewswire-FirstCall/ -- Data from four new studies examining safety and efficacy of desvenlafaxine succinate, a serotonin-norepinephrine reuptake inhibitor (SNRI) being studied as a potential treatment for adults with major depressive disorder (MDD), were presented today at the 2007 American Psychiatric Association annual meeting in San Diego, Calif., by Wyeth Pharmaceuticals, a division of Wyeth . Results from short-term studies and a six-month relapse prevention study showed that desvenlafaxine succinate improved symptoms of MDD vs. placebo in adult patients with depression. In addition, results from a 12-month safety study were presented.

"Depression is a chronic condition where a large number of treated patients often experience a relapse or a return of symptoms following a positive response to treatment," says Philip Ninan, M.D., Vice President, Neuroscience, Global Medical Affairs for Wyeth Pharmaceuticals. "We are encouraged by these clinical trials, which show that desvenlafaxine, if approved, may be an important option for the treatment of adult patients with major depressive disorder."

About the Studies

Poster NR327: Rickels K, et al. A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Desvenlafaxine Succinate for Prevention of Depressive Relapse in Adult Outpatients with Major Depressive Disorder

Study findings from the double-blind phase showed that patients who took desvenlafaxine succinate experienced a significantly longer time to relapse of MDD compared with patients who took placebo. The study also found that more patients who took desvenlafaxine succinate achieved remission (Hamilton Rating Scale for Depression [HAM-D17] score of less than or equal to 7) by Week 4 of the study than those in the placebo group. The most frequent cause for discontinuation of treatm
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