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New Study Analyses Confirm Once-Daily Seroquel XR Extended-Release,Tablets as Effective Treatment for Schizophrenia

ession, and depression. Efficacy was assessed from the change from baseline to study endpoint (Day 42) using PANSS total score as well as positive symptom, negative symptom, general psychopathology, aggression, and depression rating scores.(2)

At Day 42, there were statistically significant reductions versus placebo with all doses of SEROQUEL XR for the change in PANSS total, positive subscale, general psychopathology subscale, and hostility and aggression scores. Changes in negative symptom and depression scores of the PANSS were statistically significant versus placebo for SEROQUEL XR 600 mg/day and 800 mg/day.(2)

IMPORTANT SAFETY INFORMATION FOR SEROQUEL XR

SEROQUEL XR is indicated for the treatment of schizophrenia. Patients should be periodically reassessed to determine the need for treatment beyond the acute response.

Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk (1.6 to 1.7 times) of death compared to placebo (4.5% vs 2.6%, respectively). SEROQUEL XR is not approved for the treatment of patients with dementia-related psychosis. (See Boxed Warning.)

Hyperglycemia, in some cases extreme and associated with ketoacidosis, hyperosmolar coma, or death, has been reported in patients treated with atypical antipsychotics, including quetiapine. The relationship of atypical use and glucose abnormalities is complicated by the possibility of increased risk of diabetes in the schizophrenic population and the increasing incidence of diabetes in the general population. However, epidemiological studies suggest an increased risk of treatment-emergent, hyperglycemia-related adverse events in patients treated with atypical antipsychotics. Patients starting treatment with atypical antipsychotics who have or are at risk for diabetes should undergo fasting blood glucose testing at the beginning of and during treatment. Patients who develop symptoms of hyperglycemia should also u
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