Navigation Links
New Research Results Show That Investigational Drug Phenoxodiol,Targets Cancer Protein, Causing Cancer Cell Death

rug sensitivity to resistant cancer cells.

"Phenoxodiol has a unique mechanism of action not exhibited by other anticancer drugs in current use.," said Dr. Berridge. "By inhibiting plasma membrane electron transport selectively in cancer cells, phenoxodiol subjects these cells to stress that leads to cell death. This novel drug and its related analogues have the potential to enhance anticancer efficacy by a different mechanism, promising a new approach to management of solid tumors in a range of clinical settings. As the first compound to operate via this pathway, confirmatory evidence to validate the mechanism of action is very desirable."

Specific Findings Identify Specific Proteins Associated with Unlocking the Mystery for Why Cancer Cells don't Die the Way Healthy Cells Do

Evidence from this new study indicates that phenoxodiol inhibits proliferation of many cancer cell lines and some primary immune cells. Phenoxodiol induces the destruction of cancer cells by disrupting a stress pathway in the outer cell membrane, causing down regulation of the FLICE-inhibitory protein, FLIP, and resulting in caspase-dependent and independent degradation of the X-linked inhibitor of cell death, XIAP.

Phenoxodiol selectively limits plasma membrane electron transport in cancer cells, by binding to a cancer specific surface plasma membrane electron transport element on cancer cells thereby inhibiting their proliferation, whereas the compound has no such effect on normal healthy cells.

Multinational trial underway

Phenoxodiol in combination with carboplatin is currently being studied in a multi-national Phase III clinical trial called OVATURE, following positive findings of previous trials conducted at Yale-New Haven Hospital. The OVATURE trial will take place in 60 sites in the United States, Europe, and Australia. Preliminary results from the trial are expected within 18 months.

About phenoxodiol:

Phenoxodiol is being develo
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Suven Life Sciences Presenting Pre-clinical data of their NCE’s SUVN-502 and SUVN-507at International Brain Research Organization (IBRO) 2007 World Congress of Neuroscience
4. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
5. Researchers Discover Method for Identifying How Cancer Evades the Immune System
6. Infertile Voice Supports Stem Cell Research: RESOLVE Calls for Patient Options in Using Frozen Embryos
7. Fact Sheet: Advancing Stem Cell Research While Respecting Moral Boundaries
8. President Bush Ignores Americas Plea for Support of Stem Cell Research
9. Researchers Discover Gene For Rare Skin Disorder
10. The Christopher and Dana Reeve Foundation Expresses Disappointment Over President Bushs Veto of the Stem Cell Research Enhancement Act
11. Research on New Treatment for Neglected Disease Published in The New England Journal of Medicine
Post Your Comments:
(Date:8/21/2014)... HOUSTON , Aug. 21, 2014   Memorial Hermann ... Anderson Cancer Center today announced a new partnership to ... network of community breast care centers in the greater ... November, MD Anderson will become the exclusive provider of professional ... care centers, located in Memorial City, The Woodlands ...
(Date:8/21/2014)...  Publicis Groupe customer engagement agency Rosetta ... Healthcare Industry Group Leader, has been featured in the ... inspiring people in the life-sciences industry. Those chosen for ... marketing, technology, creativity, strategy and medicine. ... in its leading Rosetta Consulting practice. In 2012, she ...
(Date:8/21/2014)... HAMBURG, Germany , Aug. 21, 2014 /PRNewswire/ ... collaborating with Deutsches Elektronen-Synchrotron ( DESY ), a leading ... to speed up management and storage of massive volumes ... Analytics architecture based on IBM software defined technology ... data at peak performance and help scientists worldwide gain ...
Breaking Medicine Technology:Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Shannon Hartley Shines in PharmaVOICE 100 2DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3
(Date:8/22/2014)... (PRWEB) August 22, 2014 Millennium Treatment Group ... resulting in a high level of drug use among teenagers. ... fight against drug addiction and work to minimize drug abuse. ... of alcohol and drug addiction in history. According to the ... estimated 23.9 million Americans aged 12 or older—or 9.2 percent ...
(Date:8/22/2014)... The regional economy is about to get a ... grow again. The plant will invest $100 million ... production of the popular Highlander midsize sport utility vehicle. ... $4 billion. This step allows Toyota to utilize existing ... adjust its product mix to meet changing customer demand. ...
(Date:8/22/2014)... A Penn Medicine team has found that targeted ... urinary tract infections in hospital patients with urinary ... alert was simplified, the rate of improvement dramatically ... their patients need urinary catheters in the first ... need for catheters that have not been removed ...
(Date:8/22/2014)... Aug. 22, 2014 (HealthDay News) -- Many Americans know little ... the possibility of an outbreak in the United States, a ... they are worried that there will be a major Ebola ... they or an immediate family member will get sick with ... latest Harvard School of Public Health poll. However, those ...
(Date:8/22/2014)... Millennium Treatment Group, a drug ... recently launched a new website. Patients, parents, loved ... now find Millennium Treatment Group at http://www.millenniumtreatmentgroup.com ... at the beginning of July. Everything anyone would ... found on the website. There’s an About Us ...
Breaking Medicine News(10 mins):Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 3Health News:Many Americans Harbor Unfounded Fears About Ebola Outbreak: Survey 2Health News:Millennium Treatment Group Has a New Website 2
... no hard and fast rule as to how a mother should ... than glad to endorse that view as standard positions like sitting ... to override. , Take the case of Nicola Adolphe. ... daughter Deborah was born. ,As manager of a play ...
... had enough. Most Doctors are on the brink of burn ... survey conducted by the Australian Medical Association has found that ... staff shortage, outdated equipments and under trained colleagues from abroad. ... have closed down due to the shortage of doctors. The ...
... a checklist for doctors and nurse to avoid common errors ... hands by the health workers help spread disease to ... to improve patient safety around the world and lessen the ... safety is a primary concern in both developed and developing ...
... clearly raise the risk of the allergic sensitisation of children ... , however, the influence of the environment at home on ... the conclusion reached by scientists from the GSF National ... ,The study published by Chih-Mei Chen et al. in ...
... calcium and vitamin D are significantly more likely to have ... can increase risk of cognitive impairment, dementia, depression and stroke. ... and the University of North Carolina examined magnetic resonance imaging ... women) between the ages of 60 and 86 (average age ...
... of maternity units in UK is an eye-opener to prevailing ... the hospitals. In a sting operation conducted by BBC, some ... practices. ,Some of the maternity units were facing ... were overburdened with work. The midwife in charge at a ...
Cached Medicine News:Health News:New Research Promises To Take The Pain Off Breast Feeding 2Health News:New Research Promises To Take The Pain Off Breast Feeding 3Health News:UN Agencys Checklist on Health Care Error 2Health News:Cats at Home Poses Allergy Risk in Young Children 2Health News:Higher Intake of Calcium and Vitamin D Linked With Brain Lesions in Older People 2Health News:United Kingdom: Maternity Units Exposed! Leaves Much to Be Desired 2
... image quality at low light intensity. Leica ... system is specifically designed for imaging applications ... create bright, vibrant images without noise or ... by the Leica cameras allow dark and ...
Coolpix 4500 microscope package includes Coolpix 4500 digital camera, MDC-A relay lens and EH52 AC adapter....
Semi-Automated Chemistry Analyzer with model screen master. The Screen Master incorporates many powerful features in one compact unit. Useful for biochemical investigations, enzymatic, immunoturbidi...
... Geometric Data Hemastainer. Formulated to ... quality control tested on human ... staining and absence of precipitate. ... a minimum of eight hours ...
Medicine Products: