Navigation Links
New Research Demonstrates Broad Efficacy of Azixa (MPC-6827),Against Multiple Tumor Types and in Drug Resistant Cell Lines

Study Results Published in Cancer Research

TARRYTOWN, N.Y., June 15, 2007 /PRNewswire-FirstCall/ -- EpiCept Corporation today announced the results of scientific studies that (1) demonstrate that Azixa(TM) (MPC-6827) is effective in treating multiple types of human tumors in animal models, (2) reveal a mechanism by which MPC-6827 exerts its effects, and (3) show that MPC-6827 is not affected by cellular proteins known to be involved in cancer drug resistance. The study results appear in the June 15, 2007 edition of Cancer Research, a journal published by the American Association of Cancer Research (AACR).

"The results of this study demonstrate the potential of Azixa (MPC-6827) to offer significant anti-tumor activity, even in tumors expressing multi-drug resistant phenotypes," remarked Jack Talley, President and Chief Executive Officer. "These data further exemplify the potential of our proprietary Anti- cancer Screening Apoptosis Program, through which this compound was discovered."

The Cancer Research authors describe results showing that MPC-6827 displays significant activity in inhibiting the growth of a broad spectrum of solid tumor lines in athymic nude mice, including human breast, colon, pancreas, ovarian and mouse melanoma. Additional in vitro studies demonstrated that MPC-6827 exerts its effects by binding of tubulin, thereby inhibiting polymerization and leading to cell cycle arrest and apoptosis. Unlike other tubulin-disrupting cancer treatments, MPC-6827 had efficacy against tumor cells that over-expressed the three main protein transporters responsible for multidrug resistance, indicating that MPC-6827 may prove effective against drug resistant tumors in a clinical setting.

MPC-6827 is one of two compounds currently in clinical trials discovered through EpiCept's Anti-cancer Screening Apoptosis Program (ASAP). MPC-6827 is part of the EP90745 series of apoptosis inducers, which
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Suven Life Sciences Presenting Pre-clinical data of their NCE’s SUVN-502 and SUVN-507at International Brain Research Organization (IBRO) 2007 World Congress of Neuroscience
4. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
5. Researchers Discover Method for Identifying How Cancer Evades the Immune System
6. Infertile Voice Supports Stem Cell Research: RESOLVE Calls for Patient Options in Using Frozen Embryos
7. Fact Sheet: Advancing Stem Cell Research While Respecting Moral Boundaries
8. President Bush Ignores Americas Plea for Support of Stem Cell Research
9. Researchers Discover Gene For Rare Skin Disorder
10. The Christopher and Dana Reeve Foundation Expresses Disappointment Over President Bushs Veto of the Stem Cell Research Enhancement Act
11. Research on New Treatment for Neglected Disease Published in The New England Journal of Medicine
Post Your Comments:
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: ... concerning composition of matter, biological targets, mechanism of action, ... This patent application describes a novel ... (VSRNAs) which interfere with the basic homeostatic cellular processes ...
(Date:1/15/2014)... 15, 2014  According to Millennium Research Group (MRG), ... the United States and ... will expand moderately through 2022, with embolization particles ... increasing interest in drug-eluting beads (DEBs) and radioembolization ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... 5, 2011 ORBIS and its global team of ... in Ulaanbaatar, Mongolia (June 19 - July 7) aboard ... hospital with wings. The mission was supported by Alcon ... a three-week ophthalmic skills exchange and surgical program through ...
...   The world-renowned International Journal ... addresses the thermal,aspects of radiofrequency exposure on human health. ... the controversies,surrounding huge growth and use of wireless communication. ... a quantitative,assessment of the effects of thermal energy on ...
Cached Medicine Technology:ORBIS International's Flying Eye Hospital Brings Sight Saving Skills and Technology to Ulaanbaatar, Mongolia 2ORBIS International's Flying Eye Hospital Brings Sight Saving Skills and Technology to Ulaanbaatar, Mongolia 3ORBIS International's Flying Eye Hospital Brings Sight Saving Skills and Technology to Ulaanbaatar, Mongolia 4Is Heat From Radiofrequency Exposure Damaging Human Health? 2Is Heat From Radiofrequency Exposure Damaging Human Health? 3
(Date:4/24/2014)... and stressful outcomes for parents who have a child ... says a recent study led by a researcher at ... numerous and life-changing and stress levels high, the vast ... reported positive outcomes as well, a phenomenon known as ... issue of the American Journal of Orthopsychiatry . ...
(Date:4/24/2014)... in the new Institute for Biomedical Sciences at ... million federal grant to develop novel therapeutics against ... from the Eunice Kennedy Shriver National Institute Of ... Institutes of Health will support Plemper,s drug development ... least one distinct alternative compound. , Infections by ...
(Date:4/24/2014)... give than to receive at least if you,re an ... The study found that 15- and 16-year-olds who find pleasure ... members, are less likely to become depressed than those who ... money for themselves. , The researchers detail their findings in ... , The study focused on the ventral striatum, a brain ...
(Date:4/24/2014)... the influenza pH1N1 virus caused the first flu pandemic ... May 2009 and killed more than 50 people in ... mainly during flu epidemics (winter/spring seasons). , Infections ... complicated illnesses. World Health Organization has recommended Tamiflu for ... disadvantage of this drug is that it targets viral ...
(Date:4/23/2014)... researchers say clinical trials for a new experimental ... very promising. Patients treated with CPX-351, a combination ... showing better responses than patients treated with the ... myeloid leukemia is an aggressive blood cancer with ... older patients," explained Jeffrey Lancet, M.D., senior member ...
Breaking Medicine News(10 mins):Health News:Parents of severely ill children see benefits as caregivers, says study 2Health News:Study: Altruistic adolescents less likely to become depressed 2Health News:Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia 2
... Men and women of all ages are invited to enjoy this 5-day health ... ... Dr. John Spencer,Ellis invites men and women of all ages to enjoy a ... Ellis,welcomes anyone who has completed a fitness program from around the world,as well ...
... boosted pregnancy chances , , THURSDAY, Feb. 7 (HealthDay News) ... chances of becoming pregnant by up to 65 percent ... , , About 10 percent to 15 percent of ... vitro fertilization, in which a woman,s egg is fertilized ...
... ORBIS International is,saddened to announce the death ... of,directors, the Honorable Oliver Foot. He was 61 ... Oliver,s dedication to reduce human suffering caused ... a nonprofit global development,organization that transcends cultural, political ...
... with a certain gene variant drank less and ... the variant while taking the medication naltrexone, according ... Institutes of Health,s 2001-2004 COMBINE (Combined Pharmacotherapies and ... 87 percent of patients with the variant who ...
... CHASE, Md., Feb. 7 This week the,Office ... a statement that "Mr.,Heath Ledger died as the ... oxycodone, hydrocodone, diazepam, temazepam, alprazolam and,doxylamine ...We have ... accident,resulting from the abuse of prescription medications." This ...
... Finding Health and Mental Health Top the List,of Needs, ... series of tornadoes in decades, many people across the ... Cross continues to help,provide meals, shelter and clean up ... welcome help comes from Red Cross health and mental,health ...
Cached Medicine News:Health News:QueensLander Tours Presents an Adventure Boot Camp Cruise with John Spencer Ellis from Bravo's The Real Housewives of Orange County 2Health News:Acupuncture May Aid In Vitro Fertilization 2Health News:Acupuncture May Aid In Vitro Fertilization 3Health News:ORBIS International Announces the Death of the Honorable Oliver Foot, President and Board Member 2Health News:Gene variant predicts medication response in patients with alcohol dependence 2Health News:Gene variant predicts medication response in patients with alcohol dependence 3Health News:ASAM Calls for Care in the Use of, and the Prescribing of, Potentially Addictive Substances 2Health News:Tornado-Scarred States Receive American Red Cross Health Services 2Health News:Tornado-Scarred States Receive American Red Cross Health Services 3
... almost all its mechanical strength throughout the ... 915 months. Blunt thread design assists in ... maximize surgeons options. Driver design distributes ... help prevent the screw from breaking or ...
... FDA-cleared third-generation allergy test , 3gAllergy is ... It provides quantitative determination of allergen-specific IgE ... accuracy and lot-to-lot reproducibility. The assay delivers ... help you identify, monitor and manage patients ...
... Screw System is part of a series of ... screws ranging from 3.5 to 8.0 mm. Matching ... the system provides convenience and flexibility for the ... mm system may be customized using two of ...
The DePuy ACE 8.0mm Cannulated Cancellous Screw incorporates TiMAX to provide superior strength, fatigue resistance and a lower modulus of elasticity when compared to similar stainless steel devices....
Medicine Products: