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New Report Illuminates Ampligen's Unique Mechanism of Action

of dsRNAs for the induction of innate immunity. Unlike the toxic Poly I:Poly C, Ampligen is directed towards the activation of TLR-3 in the induction of innate immune responses.

The closely allied compound, Poly I : Poly C, has been used in clinical trials but has a broad range of side-effects, some of which are life-threatening. Where the studies found specific involvement of TLR-3 in conveying Ampligen(R)'s biologic properties, no such specificity was seen with poly I : poly C, thus explaining its side effect profile without compromising its potency as an immunotherapeutic.

The findings further establish the remarkable specificity of Ampligen(R) in activating the critical first line of defense against various types of pathogenic elements. The findings are pertinent to many cutting edge therapeutic topics in biotechnology today, including the enhancement of vaccine efficacy (both antiviral and anticancer) as well as strengthening biologic therapy (interferons, interleukins, etc.) of various serious human diseases as well as enhancing traditional antivirals such as Tamiflu(R) and Relenza(R).

The experimental therapeutic Ampligen(R) is perhaps the best studied TLR activator in human clinical trials to date, having been administered more than 75,000 times in approximately 15 clinical trials of which four were very well-controlled (placebo-controlled, randomized, multi-center, double-blinded).

"These scientific findings go a long way toward explaining how a single, relatively simple compound, Ampligen(R), can repeatedly show therapeutic promise in such a broad array of indications. The findings may also have broad economic implications for the American biotechnology sector," commented Dr. William A. Carter, Chairman and CEO of Hemispherx Biopharama, Inc. "According to a recent KPMG Bioscience report, our sector recently achieved a new high of $70 billion in revenues a year, but is now faced with many very short product life cycles, large po
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