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New Point-of-Care Methods to Measure Coronary and Cerebrovascular Risk

correlate with coronary angiography, stress testing, and a history of heart attack. Tzou and coworkers (Am Heart J. 2005;150:1135-9) recently tested the ability of the PREVU(x) test to predict CIMT. They found that CIMT was indeed highest among individuals in the highest quartile of skin cholesterol levels. The correlation held up even when statistical analysis controlled for other risk factors.

The PREVU(x) test requires only two drops of solution placed on the palm of the hand. The first, digitonin, binds to skin cholesterol. The second contains an enzyme substrate that allows readout with a spectrophotometer. The test can be performed in minutes. PREVU(x) is marketed by McNeil Consumer Healthcare and approved for use in North America and Europe. The manufacturer has also announced plans for a quantitative laboratory-based version and a semiquantitative home-based version.

All of these new, noninvasive tests for atherosclerosis risk will make it easier, and hopefully more cost-effective, to anticipate and intervene upon one of the worlds most prevalent disease processes.
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