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New Pfizer Oncology Data Across Numerous Cancer Types to be,Presented at ASCO

oved by the FDA," said Charles Baum, MD, vice president of Pfizer Global Research and Development. "We are committed to investigating the role SUTENT may play in the treatment of advanced breast cancer through a comprehensive phase III program."

SUTENT (sunitinib malate) Phase III Trials in Breast Cancer

This phase III research program in advanced breast cancer will investigate sunitinib malate in multiple settings, including first, second and later lines, as both a single agent and in various combinations, including: combined with standard of care (SOC) chemotherapies versus SOC chemotherapies alone and combined with SOC chemotherapies versus other targeted therapies. The studies will evaluate sunitinib malate in patients with various types of advanced breast cancer including HER2 negative and positive, and previously treated advanced triple receptor negative (ER-, PR- and HER2-).

The phase II and III randomized, open-label studies that are currently enrolling include:

Phase III

-- SUN 1094: Sunitinib malate + paclitaxel versus bevacizumab + paclitaxel in first-line advanced breast cancer

-- SUN 1064: Sunitinib malate + docetaxel versus docetaxel alone in HER2- advanced breast cancer

-- SUN 1099: Sunitinib malate + capecitabine versus capecitabine alone in previously treated advanced breast cancer

-- SUN 1107: Single-agent sunitinib malate versus capecitabine in previously treated advanced breast cancer

Phase II

-- SUN 1077: Single-agent sunitinib malate versus chemotherapy in previously treated advanced triple receptor negative (ER-, PR-, and HER2-) breast cancer

-- SUN 1067: Sunitinib malate + trastuzumab versus trastuzumab + placebo in advanced breast cancer

About SUTENT(R) (sunitinib malate)

SUTENT is a multi-kinase inhibitor approved for the treatment of advanced renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST) after disease progression on or intolera
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