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New Information on the Potential of Plasmin Shared at ISTH Congress

e improved patient outcomes, and these are currently being evaluated in the clinic."

About Plasmin (Human), TAL-05-00018

Plasmin (Human), TAL-05-00018, is a plasma-derived thrombolytic protein currently under development by Talecris Biotherapeutics for treating acute peripheral arterial occlusion. Plasmin is a catheter-delivered, direct and locally acting, fibrin-specific thrombolytic with additional potential applications in other acute bleeding disorders including deep vein thrombosis and ischemic stroke. The plasmin molecule contains fibrin-binding domains not present in other direct thrombolytics. Plasmin is rapidly inactivated by alpha-2 antiplasmin when not bound to fibrin therefore minimizing risk of systemic bleeding.

(delta) plasmin, TAL-6003

Talecris scientists are utilizing biotechnology applications to produce modified Plasmin molecules that may exhibit improved fibrinolytic properties. (delta) plasmin ((delta)Pm), TAL-6003, is a simplified form of human plasmin where Kringle 1, which carries the fibrin and alpha-2 antiplasmin-binding site, is directly attached to the serine protease domain. Early research on this modified form of the plasmin molecule reinforces the importance of fibrin binding for its fibrinolytic potency. This attribute is critical for direct thrombolytics to maintain efficacy under dynamic flow conditions, i.e., not get washed away from the clot as blood flow begins to be restored.

About Talecris Biotherapeutics: Inspiration. Dedication. Innovation.

Talecris Biotherapeutics is a global biotherapeutic and biotechnology company that discovers, develops and produces critical care treatments for people with life-threatening disorders in a variety of therapeutic areas including immunology, pulmonology, and hemostasis. Talecris is proudly building upon a 60-year legacy of innovation and a commitment to improving the lives of people who rely on its therapeutic products. With an emphasis on scientific
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