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New Flu Vaccine From PepTcell Could Provide Immunity Against All,Strains of Influenza Virus

ains in in vitro tests. This experiment confirmed that the peptide sequences in Flu-V are highly conserved across strains, and that these peptides are naturally presented on the surface of flu-infected cells, and therefore can be recognised by the immune system.

When the immunised mice were subsequently challenged with a lethal dose of influenza, the researchers found that fifty seven percent of the mice who had been immunised with the FLU-v vaccine survived, compared with none of the mice in the control group.

Greg Stoloff, Managing Director of PepTcell, commented: "These results suggest that PepTcell's FLU-v vaccine could eliminate the need for annual flu vaccination as the immunity generated targets regions of the virus that remain constant. The results also suggest that FLU-v has the potential to provide effective protection against a pandemic flu strain by enabling stockpiling and the initiation of a worldwide vaccination program ahead of an outbreak."

PepTcell is in the process of finalising all the manufacturing processes for its vaccines, and expects FLU-v to enter Phase I clinical trials during 2008.

Notes for Editors

About the European Journal of Immunology

Gregory A Stoloff, Wilson Caparros-Wanderly: Synthetic multiepitope peptides identified in silico induce protective immunity against multiple influenza serotypes. European Journal of Immunology. 2007. Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.

About PepTcell Ltd

PepTcell is a biotechnology company focused on applying its breakthrough technology to the development of a new class of vaccines - T-cell vaccines - against highly mutagenic viruses. The Company began operating in 2004, however the founding shareholders and key employees have been working on this novel concept for over 20 years.

Since its inception, the Company has completed the majority of its pre-clinical work for its influenza and HIV vaccines. Pe
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