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New England Journal of Medicine Publishes New Data on Gardasil,,Merck's Cervical Cancer Vaccine

rformance. No forward-looking statement can be guaranteed and actual results may differ materially from those projected. Merck undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect Merck's business, particularly those mentioned in the risk factors and cautionary statements in Item 1A of Merck's Form 10-K for the year ended Dec. 31, 2006, and in its periodic reports on Form 10-Q and Form 8-K, which the Company incorporates by reference.

GARDASIL(R) is a registered trademark of Merck & Co., Inc., Whitehouse Station, N.J., U.S.A.

Prescribing information and patient product information for GARDASIL(R) is attached and is also available at www.gardasil.com. -0-

MERCK & CO., INC.

Whitehouse Station, NJ 08889, USA                              9682301

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GARDASIL(R)

(Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant

Vaccine)


DESCRIPTION


    GARDASIL* is a non-infectious recombinant, quadrivalent vaccine

prepared from the highly purified virus-like particles (VLPs) of the

major capsid (L1) protein of HPV Types 6, 11, 16, and 18. The L1

proteins are produced by separate fermentations in recombinant

Saccharomyces cerevisiae and self-assembled into VLPs. The

fermentation process involves growth of S. cerevisiae on

chemically-defined fermentation media which include vitamins, amino

acids, mineral salts, and carbohydrates. The VLPs are released from

the yeast cells by cell disruption and purified by a series of

chemical and physical methods. The purified VLPs are adsorbed on

preformed aluminum-containing adjuvant (amorphous aluminum

hydroxyphosphate sulfate). The quadrivalent HPV VLP vaccine is a

sterile liquid suspension that is prepared 
'"/>




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