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New England Journal of Medicine Publishes New Data on Gardasil,,Merck's Cervical Cancer Vaccine

t) and GARDASIL was non-inferior whether they were administered at the same visit or at a different visit. INDICATIONS AND USAGE GARDASIL is a vaccine indicated in girls and women 9-26 years of age for the prevention of the following diseases caused by Human Papillomavirus (HPV) types 6, 11, 16, and 18: -- Cervical cancer -- Genital warts (condyloma acuminata) and the following precancerous or dysplastic lesions: -- Cervical adenocarcinoma in situ (AIS) -- Cervical intraepithelial neoplasia (CIN) grade 2 and grade 3 -- Vulvar intraepithelial neoplasia (VIN) grade 2 and grade 3 -- Vaginal intraepithelial neoplasia (VaIN) grade 2 and grade 3 -- Cervical intraepithelial neoplasia (CIN) grade 1 CONTRAINDICATIONS Hypersensitivity to the active substances or to any of the excipients of the vaccine. Individuals who develop symptoms indicative of hypersensitivity after receiving a dose of GARDASIL should not receive further doses of GARDASIL. PRECAUTIONS General As for any vaccine, vaccination with GARDASIL may not result in protection in all vaccine recipients. This vaccine is not intended to be used for treatment of active genital warts; cervical cancer; CIN, VIN, or VaIN. This vaccine will not protect against diseases that are not caused by HPV. GARDASIL has not been shown to protect against diseases due to non-vaccine HPV types. As with all injectable vaccines, appropriate medical treatment should always be readily available in case of rare anaphylactic reactions following the administration of the vaccine. The decision to administer or delay vaccination because of a current or recent febrile illness depends largely on the severity of the symptoms and their etiology. Low-grade fever itself and mild upper respiratory infection are not generally contraindications to vaccination. Individuals with impaired immune responsiveness, whether due
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