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New England Journal of Medicine Publishes New Data on Gardasil,,Merck's Cervical Cancer Vaccine

, 72.2) 199 4.6 (4.3, 5.0) ---------------------------------------------------------------------- Month 36 196 59.7 (48.5, 73.5) 193 4.8 (4.4, 5.2) ---------------------------------------------------------------------- * The PPI population consisted of individuals who received all 3 vaccinations within pre-defined day ranges, did not have major deviations from the study protocol, met predefined criteria for the interval between the Month 6 and Month 7 visit, and were naive (PCR negative and seronegative) to the relevant HPV type(s) (Types 6, 11, 16, and 18) prior to dose 1 and through 1 month Postdose 3 (Month 7). **Number of subjects randomized to the respective vaccination group who received at least 1 injection. ***Number of subjects in the per-protocol analysis with data at the specified study time point. +mMU = milli-Merck units. Note: These data are from Protocol 007. ---------------------------------------------------------------------- Table 4 compares anti-HPV GMTs 1 month Postdose 3 among subjects who received Dose 2 between Month 1 and Month 3 and subjects who received Dose 3 between Month 4 and Month 8 (Table 4). Table 4 Summary of GMTs for Variation of Dosing Regimen ---------------------------------------------------------------------- Anti-HPV 6 Anti-HPV 11 Variation of Dosing ----------------------------------------- Regimen N GMT N GMT (95% CI) (95% CI) ====================================================================== Dose 2 ---------------------------------------------------------------------- Early* 570.9 824.6 883 (542.2, 601.2) 888 (776.7, 875.5) ------------------------------------------------------------
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