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New England Journal of Medicine Publishes New Data on Gardasil,,Merck's Cervical Cancer Vaccine

her types. GARDASIL was efficacious in reducing the incidence of CIN (any grade including CIN 2/3); AIS; genital warts; VIN (any grade); and VaIN (any grade) related to vaccine HPV types in those who were PCR negative and seronegative at baseline (Table 1). Table 1 Analysis of Efficacy of GARDASIL in the PPE* Population** ---------------------------------------------------------------------- GARDASIL Placebo ---------------------- Population Number Number % Efficacy (95% CI) n of n of cases cases ====================================================================== HPV 16- or 18-related CIN 2/3 or AIS ---------------------------------------------------------------------- Protocol 005*** 755 0 750 12 100.0 (65.1, 100.0) ---------------------------------------------------------------------- Protocol 007 231 0 230 1 100.0 (-3734.9, 100.0) ---------------------------------------------------------------------- FUTURE I 2200 0 2222 19 100.0 (78.5, 100.0) ---------------------------------------------------------------------- FUTURE II 5301 0 5258 21 100.0+ (80.9, 100.0) ---------------------------------------------------------------------- Combined Protocols++ 8487 0 8460 53 100.0+ (92.9, 100.0) ------------------------------------------------====================== HPV 6-, 11-, 16-, 18-related CIN (CIN 1, CIN 2/3) or AIS ---------------------------------------------------------------------- Protocol 007 235 0 233 3 100.0 (-137.8, 100.0) ---------------------------------------------------------------------- FUTURE I 2240 0 2258 37 100.0+ (89.5, 100.0) -----------------------------------------------
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