( her types. GARDASIL was efficaciou...)New England Journal of Medicine Publishes New Data on Gardasil,,Merck's Cervical Cancer Vaccine,Health

her types. GARDASIL was efficacious in reducing the incidence of CIN (any grade including CIN 2/3); AIS; genital warts; VIN (any grade); and VaIN (any grade) related to vaccine HPV types in those who were PCR negative and seronegative at baseline (Table 1). Table 1 Analysis of Efficacy of GARDASIL in the PPE* Population** ---------------------------------------------------------------------- GARDASIL Placebo ---------------------- Population Number Number % Efficacy (95% CI) n of n of cases cases ====================================================================== HPV 16- or 18-related CIN 2/3 or AIS ---------------------------------------------------------------------- Protocol 005*** 755 0 750 12 100.0 (65.1, 100.0) ---------------------------------------------------------------------- Protocol 007 231 0 230 1 100.0 (-3734.9, 100.0) ---------------------------------------------------------------------- FUTURE I 2200 0 2222 19 100.0 (78.5, 100.0) ---------------------------------------------------------------------- FUTURE II 5301 0 5258 21 100.0+ (80.9, 100.0) ---------------------------------------------------------------------- Combined Protocols++ 8487 0 8460 53 100.0+ (92.9, 100.0) ------------------------------------------------====================== HPV 6-, 11-, 16-, 18-related CIN (CIN 1, CIN 2/3) or AIS ---------------------------------------------------------------------- Protocol 007 235 0 233 3 100.0 (-137.8, 100.0) ---------------------------------------------------------------------- FUTURE I 2240 0 2258 37 100.0+ (89.5, 100.0) -----------------------------------------------
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