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New Data from the US and Japan Support: No Established Causal Link,Between Neuropsychiatric Symptoms and Treatment with Tamiflu US,Databases Indicate Psychiatric Symptoms Lower in Influenza Patients,Taking Tamiflu Versus Those Not Taking Tamiflu

er, said: "Patient safety is a primary concern for Roche and since the introduction of Tamiflu, Roche has continuously monitored and reviewed post-marketing safety information and provides regular updates to the regulatory agencies".
Roche is aware that a number of reports have been received in Japan of neuropsychiatric symptoms including delirium, with associated abnormal behavior, and very rare cases of death in patients suffering from influenza who have also been taking the antiviral Tamiflu. The Japanese Ministry for Health and Welfare stated that they see no causal relationship between these cases and Tamiflu.

Tamiflu has now been used in over 45 million influenza patients worldwide (2) and treatment with Tamiflu has proven successful in reducing the duration and severity of the disease. Post marketing surveillance has confirmed that rates of neuropsychiatric events in patients with influenza also taking Tamiflu are uncommon, occurring in around 1 in 37,000 patients (2). In addition, reports of such events leading to death are extremely rare, occurring in around 1 out of every 5 million influenza patients treated (2). No causal link between such events and Tamiflu has been established.

About Roche
Headquartered in Basel, Switzerland, Roche is one of the world's leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As the world's biggest biotech company and an innovator of products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people's health and quality of life. Roche is the world leader in diagnostics and drugs for cancer and transplantation, a market leader in virology and active in other major therapeutic areas such as autoimmune diseases, inflammation, metabolism and central nervous system. In 2006 sales by the Pharmaceuticals Division totalled 33.3 billion Swiss francs, and the Diagnostics D
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