Navigation Links
New Data for Cytogen's QUADRAMET Reported at Annual ASCO Meeting

-limiting toxicity (DLT) was evaluated based on the first cycle of treatment and DLT was not reached in 21 patients who received the combination regimen including patients who received the full FDA approved doses of each agent. Further, all patients' platelet and neutrophil counts recovered to protocol defined levels and times allowing for re-treatment after cycle one. At baseline, median Gleason Score was eight, median PSA values were 162 ng/ml and 43% of patients had previously received taxane-based chemotherapy. Following treatment, 12 out of 21 patients achieved a 50% or greater decline in PSA. Data on progression-free survival are pending.

The authors concluded that repetitive dosing of QUADRAMET and docetaxel was feasible and well-tolerated. Clinically significant hematologic toxicity was rare and does not appear to be related to dose or disease burden. Plans are underway for a multi-center Phase 2 study with Memorial Sloan-Kettering Cancer Center and other leading prostate cancer centers.

"With bone pain representing a significant quality-of-life concern for patients with metastatic prostate cancer, we wanted to see if we could combine QUADRAMET, an FDA-approved drug to treat bone pain, with docetaxel, an FDA-approved drug to treat late stage prostate cancer, and administer both at their respective, FDA-approved therapeutic doses without compromising patient safety," explained Michael J. Morris, M.D., an oncologist specializing in prostate cancer at Memorial Sloan-Kettering Cancer Center. "The Phase 1 data demonstrate that repeated doses of QUADRAMET are safe and do not appear to impair the effective delivery of docetaxel in most patients."

"Phase 1 trial with combination of docetaxel (D) plus samarium-13 (Sm 153) in patients (pts) with hormone refractory prostate cancer (HRPC)" by Sinibaldi et al. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD (Abstract No. 15547, published in the ASCO proceedings)

Simil
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Preclinical Data on Cytogens Technology to be Reported at the AACR Annual Meeting
2. New Clinical Data for Cytogens Quadramet and Prostacint to be Reported at Upcoming Major Medical Meetings
3. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
4. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
5. Clinical Data Reported on Vidaza in Hematologic Malignancies and Advanced Solid Tumors
6. ImmunoGen, Inc. Announces Clinical Findings for Three TAP Compounds for Solid Tumors Are to be Reported at ASCO
7. VEGF Trap-Eye Phase 2 Wet AMD Results Reported at ARVO Annual Meeting
8. Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine
9. CuraGen and TopoTarget Announce New Clinical Results With Belinostat to be Reported at Upcoming Major Medical Meetings
10. Positive Interim Phase 2 Data Reported for VEGF Trap-Eye in Age-Related Macular Degeneration
11. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Data for Cytogen QUADRAMET Reported Annual ASCO Meeting
(Date:5/22/2015)... May 22, 2015  Amgen (NASDAQ: ... commenced termination of its participation in the ... (LON:AZN, STO:AZN and NYSE: AZN ).  ... development for patients with moderate-to-severe plaque psoriasis, ... was based on events of suicidal ideation ...
(Date:5/22/2015)... HILL, N.C. , May 22, 2015 /PRNewswire/ ... critical to pharmaceutical brand recognition and success. ... LLC conducted a study to provide pharmaceutical and ... of investment (FTEs and budget) that are being ... Pharmaceutical and biotech marketing managers can utilize this ...
(Date:5/22/2015)... 22, 2015 Electrophysiologist Kevin Makati, M.D. ... to Boston, MA to ... Heart Rhythm Society conference. These scientific sessions drew ... the ideas, people and technology that propel their ... hybrid, minimally invasive cardiac operation that combines the ...
Breaking Medicine Technology:Amgen to terminate participation in co-development and commercialization of brodalumab 2Amgen to terminate participation in co-development and commercialization of brodalumab 3Amgen to terminate participation in co-development and commercialization of brodalumab 4Amgen to terminate participation in co-development and commercialization of brodalumab 5Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3
...   " The   Obama administration will offer loans ... in adopting technology to improve healthcare quality." ... records . " What is Europe,s ... IT programmes and initiatives are currently taking place across the entire ...
... ? Sosei Group Corporation ("Sosei"; TSE Mothers ... Pharma Co., Ltd. ("Activus") is to receive a grant ... New Energy and Industrial Technology Development Organization (NEDO), an ... and Industry (METI) as a part of their FY2011 ...
Cached Medicine Technology:Innovations in E-Health & Informatics Europe: The Need for a European EHealth Strategy 2Sosei to Receive Grant from NEDO's FY2011 Innovation Promotion Programme for Development of Innovative Ophthalmic Solutions 2Sosei to Receive Grant from NEDO's FY2011 Innovation Promotion Programme for Development of Innovative Ophthalmic Solutions 3
(Date:5/25/2015)... 2015 ProDrop Light Show allows users ... light backdrops with a click of a mouse. Users have full ... all within Final Cut Pro X. , ProDrop Light Show gives ... zones, kaleidoscope and much more leaving infinite possibilities all within Final ... zones and text presets, users can apply their very own media ...
(Date:5/25/2015)... TX (PRWEB) May 25, 2015 Decora Preset ... company ‘Leviton’ is now available on ‘The Hardware City.’ The ... user has to set a time and the related electronic ... When contacted a representative of the company said, “We are ... Hardware City.’ Now customers can buy Countdown Timer Switch in ...
(Date:5/24/2015)... (PRWEB) May 24, 2015 Women’s ... to take pressure measurements in patients’ bladder and urethra. ... usually orders it if they have reported symptoms of ... , Women’s Excellence in Bladder Control is a ... urinary leakage or problems with overall control of their ...
(Date:5/24/2015)... May 24, 2015 Indiana Fiber Network, ... announces Midwest Telecom of America, Inc. (MTA) has selected ... to Cory Childs, IFN Enterprise Sales Manager, fiber route ... “IFN’s fiber transport provides MTA with the diverse ... their Tier 1 Internet and voice carriers located at ...
(Date:5/23/2015)... (PRWEB) May 23, 2015 On May ... powers of a youngster's yogic power learned through meditation ... Nithyananda Swami in Bangalore, India. , Yogamaatha, a nine-year-old ... than 50 high profile professionals attending the 2015 Business ... reading fluently -- blindfolded. , In a demonstration ...
Breaking Medicine News(10 mins):Health News:Developers at Pixel Film Studios Release of ProDrop Light Show for Final Cut Pro X. 2Health News:Leviton's Decora 60 Minute Countdown Timer Available On ‘The Hardware City’ 2Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3
... may have implications for labor anesthesia, orthopedics and more , ... holy grails of local anesthesia is the ability to achieve a ... function. Now, researchers at Children,s Hospital Boston have discovered an anesthetic ... work in humans as well as it did in rats, it ...
... , , Rare, but serious, liver ... Feb. 1 The U.S. Food and Drug Administration today ... disorder, has been reported in some HIV patients taking Videx/Videx ... Videx is an antiretroviral medicine first approved by the FDA ...
... projects will combat global diseases , INDIANAPOLIS , ... its next global cause, and its International Board of Trustees ... Neglected Tropical Diseases for their Neglected Tropical Diseases (NTDs) proposal; ... joint malaria proposal; and UNICEF for its proposal on maternal ...
... , LIVERMORE, Calif. , Feb. 1 ... news outlets have recently featured headline stories about a clinical ... not at all surprised by the attention this study is ... and Chief Operating Officer of Halt Medical, Inc., a medical ...
... The brain,s innate interest in the new and different ... to research published by the American Psychological Association. In ... place they got cocaine. Novelty could help ... for the many addicts with novelty-craving, risk-taking personalities, the ...
... that pandemic H1N1 influenza of swine origin has distinct means ... in the pathogenic severity of avian flu viruses. The ... Responses of the 2009 Pandemic H1N1 Influenza Virus in ex ... Tract," appears published online ahead of print in the April ...
Cached Medicine News:Health News:Anesthetic Approach Stops Pain Without Affecting Motor Function 2Health News:Anesthetic Approach Stops Pain Without Affecting Motor Function 3Health News:FDA Announces Safety Risk Associated with HIV Drug 2Health News:Kiwanis Selects Three Finalists for Worldwide Service Project 2Health News:Kiwanis Selects Three Finalists for Worldwide Service Project 3Health News:Kiwanis Selects Three Finalists for Worldwide Service Project 4Health News:Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts 2Health News:Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts 3Health News:Of swine, birds and men -- pandemic H1N1 flu 2
Inquire...
... for Subcellular Fractionation, Proteins and ... (30,000 rpm) with fixed-angle rotor ... up to 85 mL • ... to 40° C • Rotors ...
... The compact Allegra X-22 Series is up to ... With a library of 11 rotors, the Allegra X-22 ... Features: Only 18 inches / 46 ... to 22,065 x g 3 different ways to ...
... Fractionation, Proteins and Viruses • ... with fixed-angle rotor • Spin ... 85 mL • Operating temperature ... C • Rotors certified by ...
Medicine Products: