Navigation Links
New Data for Cytogen's QUADRAMET Reported at Annual ASCO Meeting

CHICAGO--(BUSINESS WIRE)--Jun 4, 2007 - Cytogen Corporation (NASDAQ: CYTO) today reported results from clinical trials demonstrating that QUADRAMET (samarium Sm-153 lexidronam injection) can be safely administered to prostate cancer patients who are also receiving the chemotherapy docetaxel (Taxotere(R), Sanofi-Aventis). Clinical data also support further evaluation of the combination regimen for the treatment of prostate cancer in a Phase 2 program. The results were presented and/or published at the 43rd Annual Meeting of the American Society of Clinical Oncology (ASCO) taking place in Chicago, Illinois and are summarized herein.

ASCO Abstracts

"Phase 1 study of docetaxel and (153)Sm-lexidronam repetitively administered for castrate metastatic prostate cancer" by Morris M.J. et al. Memorial Sloan-Kettering Cancer Center (Abstract No. 5152, Poster No. L6)

Despite a favorable safety and efficacy profile, the routine and repetitive use of QUADRAMET for the palliation of pain from cancer that has spread to the bone has historically been limited in combination settings due to concerns regarding the potential for overlapping toxicities.

Accordingly, the objective of this open-label Company-sponsored Phase 1 study was to evaluate the safety and feasibility of repetitive co-administration of docetaxel and QUADRAMET in twenty-eight hormone-refractory prostate cancer patients with progressive disease and at least three bone metastases confirmed through a bone scan. In addition, early clinical data suggest synergistic effects between QUADRAMET and chemotherapy; therefore, as a secondary objective the anti-tumor effects of the combined regimen were also assessed.

Patients received repeated escalating doses of the combination of QUADRAMET (at doses up to the full FDA-approved doses of 1.0 mCi/kg, given every six to nine weeks) and docetaxel (at doses up to 75 mg/m2 given every three weeks). Dose
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Preclinical Data on Cytogens Technology to be Reported at the AACR Annual Meeting
2. New Clinical Data for Cytogens Quadramet and Prostacint to be Reported at Upcoming Major Medical Meetings
3. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
4. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
5. Clinical Data Reported on Vidaza in Hematologic Malignancies and Advanced Solid Tumors
6. ImmunoGen, Inc. Announces Clinical Findings for Three TAP Compounds for Solid Tumors Are to be Reported at ASCO
7. VEGF Trap-Eye Phase 2 Wet AMD Results Reported at ARVO Annual Meeting
8. Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine
9. CuraGen and TopoTarget Announce New Clinical Results With Belinostat to be Reported at Upcoming Major Medical Meetings
10. Positive Interim Phase 2 Data Reported for VEGF Trap-Eye in Age-Related Macular Degeneration
11. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Data for Cytogen QUADRAMET Reported Annual ASCO Meeting
(Date:10/20/2014)... , 20 de octubre de 2014 /PRNewswire/ ... el campo de la pulmonología intervencional, anunció hoy ... RENEW, casi 3 meses antes de lo programado. El ... exención de dispositivo de investigación (IDE) aprobada por ... el sistema de espiral de reducción de volumen ...
(Date:10/20/2014)...  ResMed (NYSE: RMD ) today ... program, a comprehensive suite of software and service ... health care providers. ResMed Data ... information. It integrates valuable sleep and respiratory treatment ... platforms with customers, in-house or third-party electronic health ...
(Date:10/20/2014)...  AnaptysBio, Inc., a leader in the discovery ... appointment of Marco Londei , M.D. as ... preclinical and clinical development of AnaptysBio,s proprietary antibody ... welcome Dr. Londei to AnaptysBio,s executive leadership team," ... Executive Officer of AnaptysBio. "Dr. Londei,s extensive expertise ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3ResMed Launches ResMed Data Exchange 2AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... /PRNewswire-Asia/ -- ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; ... var shortURL = ""; BitlyCB.alertResponse = function(data) { ... the first one. for (var r in data.results) { first_result = data.results[r]; break; } for (var key ...
... Senior Director -- OXFORD, England, August 31, 2010 ... ... var ... by longUrl, so we need to grab the first one. for (var r in data.results) { first_result ...
Cached Medicine Technology:ScinoPharm to Invest in Tanvex Biologics 2ScinoPharm to Invest in Tanvex Biologics 3ScinoPharm to Invest in Tanvex Biologics 4ScinoPharm to Invest in Tanvex Biologics 5ScinoPharm to Invest in Tanvex Biologics 6PharmaVentures Appoints Paul Phull as Senior Director 2PharmaVentures Appoints Paul Phull as Senior Director 3PharmaVentures Appoints Paul Phull as Senior Director 4PharmaVentures Appoints Paul Phull as Senior Director 5PharmaVentures Appoints Paul Phull as Senior Director 6
(Date:10/22/2014)... October 22, 2014 Richard Carlson, Managing ... industry leader with over 25 years experience. Mr. ... in the areas related to EDI, B2B Commerce, RFID ... an Editorial Advisory Board member for Pharmaceutical Commerce Magazine ... Blue Fin Group is a management and technology consulting ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... undergoing in vitro fertilization (IVF) are only about half as ... assisted reproduction technique, new research indicates, and the racial disparity ... study, about 31 percent of white patients became pregnant after ... Analyzing more than 4,000 IVF cycles over two years to ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... A crucial part of conventional in vitro fertilization (IVF) -- ... instead take place in a device inside the vagina, new ... contend that the device, called an INVOcell, might sharply cut ... also make the technology more accessible to those who don,t ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... who was diagnosed with Ebola while working for NBC News ... can leave the special isolation unit at Nebraska Medical Center in ... the hospital said Tuesday. A blood test confirmed by the ... 33, can head home to Providence, R.I., NBC News ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is offering ... a damaged mitral valve as the heart continues to ... Abbott Vascular , is designed to treat degenerative ... which the heart’s mitral valve leaflets fail to close ... left ventricle into the left atrium. The heart must ...
Breaking Medicine News(10 mins):Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
... for weight loss alone, other plans also work well, studies ... diet helps people shed as many pounds as a low-fat ... plan may be better at helping lower blood pressure, researchers ... of the Archives of Internal Medicine , found that ...
... could raise risk for heart disease later , MONDAY, Jan. ... pregnancy have blood pressure problems at birth that persisted through ... "What is of concern is that the problems are present ... a senior research scientist in the department of women and ...
... ... Men Say They Feel Inadequate , ... January 25, 2010 -- Struggling to get pregnant can be a serious blow to the self-esteem ... (71 percent) women said that infertility makes them feel flawed, while half of men (50 percent) ...
... Jan. 25 During a visit today to Avonworth ... Secretary of Education Gerald Zahorchak commended the school for ... all Pennsylvania children are overweight or obese, putting them ... like Avonworth are making the health of children a top priority ...
... higher rates of specific musculoskeletal injuries and medical conditions ... Harber in the Faculty of Physical Education and Recreation ... paper, depending on the sport, there can be a ... between male and female athletes. That,s because many training ...
... ... Flu: No Waiting in Long Lines , ... San Diego, Calif. (Vocus) January 25, 2009 -- U.S. HealthWorks Medical Group, a ... they are offering H1N1 vaccine shots for $15 per shot for both walk-ins – no ...
Cached Medicine News:Health News:For Lower Blood Pressure, Low-Carb Diet May Be Best 2Health News:For Lower Blood Pressure, Low-Carb Diet May Be Best 3Health News:Newborns of Smokers Have Abnormal Blood Pressure 2Health News:Newborns of Smokers Have Abnormal Blood Pressure 3Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 2Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 3Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 4Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 5Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 6Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 7Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 8Health News:State Health, Education Leaders Hail Avonworth Middle School in Allegheny County for Boosting Physical Activity Among Students 2Health News:Female athletes injured more than male athletes 2Health News:U.S. HealthWorks in San Diego Region Offering $15 H1N1 Vaccinations for both Walk-Ins and On-Site 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: