( drug in a more gradualpattern compared...)New Data Suggests Less Abuse-Related Effects For OROS,Methylphenidate,Health

Researchers were able to determine the direct effect on the subjects' perception and enjoyment of the medications tested, drug-liking features that are thought to be associated with a medication's potential for abuse. At comparable doses, abuse-related effects were lower when subjects received the OROS(R) methylphenidate formulation.

Pharmacodynamics of potential abuse were assessed with Visual Analog Scales (VASs). The magnitude of scores on the VAS scales was ranked (lowest to highest) as placebo < OROS(R) methylphenidate (MPH) 54 mg, < OROS(R) MPH 108 mg, < immediate-release (IR) MPH 50 mg and < IR MPH 90 mg. For the VAS Drug Liking scores, OROS(R) MPH 54 mg was significantly lower than IR MPH 50 mg (P<0.05), and OROS(R) MPH 108 mg was consistently lower than IR MPH 90 mg. For VAS Good Effects and VAS High, both OROS(R) MPH doses had significantly lower scores than comparable IR MPH doses (P<0.05) for more time points.

About ADHD

Attention Deficit Hyperactivity Disorder (ADHD) is a common and treatable medical condition, which includes a variable attention span and/or hyperactivity or impulsivity. According to the National Institutes of Health (NIH), ADHD is one of the most common mental disorders in childhood. It affects an estimated four million children in the United States(2). Studies suggest males are more likely to be diagnosed with ADHD than females because of misconceptions and differences in symptoms.

Important Safety Information

OROS(R) methylphenidate should not be taken by patients with significant anxiety, tension, or agitation; allergies to methylphenidate or other ingredients in OROS(R) methylphenidate; glaucoma; Tourette's syndrome, tics or family history of Tourette's syndrome; or current/recent use of monoamine oxidase inhibitors (MAOIs). Children under six years of age should not take OROS(R) methylphenidate.
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