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New Data Show Xenical Significantly Reduces Cardiovascular Risk and,More Than Doubles Weight Loss Achieved in Overweight and Obese,People

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- Blood pressure (SBP: -6.45 mmHg vs. -3.47 mmHg, p(less than)0.01; DBP: -4.31 mmHg vs. -3.11 mmHg, p=NS). 15.3% of patients treated with Xenical returned to normal blood pressure vs. 8.7% receiving placebo (p(less than)0.05)

- Blood glucose levels - HbA1c (-0.41% vs. -0.03%, p(less than)0.0001)

- Insulin (-25.02 pmol/l vs. -14.17 pmol/l, p(less than)0.01)

- Fasting glucose (-1.23 mmol/l vs. -0.38mmol/l, p(less than)0.0001)

- Total cholesterol (-4.19% vs. 0.77%, p(less than)0.0001) and LDL cholesterol (-7.32% vs. 1.98%, p(less than)0.0001) >>

Xenical patients more than doubled their weight loss vs. placebo (-4.83kg vs. -1.49kg, p(less than)0.0001), which was also reflected in reduced waist circumference (-5.20cm vs. -1.98cm, p(less than)0.0001). In patients who responded early to treatment (greater than or equal to 5% weight loss at 3 months)(X), Xenical produced even greater changes in blood pressure (SBP/DBP: -13.16/-7.83 mmHg), HbA1c (-0.84%), insulin (-38.72 pmol/l), fasting glucose (-1.92 mmol/l) and weight (-9.61kg) vs. placebo. Blood pressure normalisation was more than two-fold greater with Xenical vs. placebo (24.2% vs. 10.5%). Data from two additional study analyses presented at ECO also confirm Xenical's role in reducing cardiovascular risk:

- Obese patients with hypertension who responded early to treatment with Xenical experienced greater reductions in weight, waist circumference and lipid levels vs. placebo. 48% of patients treated with Xenical returned to normal blood pressure levels vs. 40.2% of placebo patients(6).

- Xenical was also shown to improve risks associated with the metabolic syndrome (based on NCEP ATP III criteria). Of particular note was the large improvement in LDL cholesterol with Xenical vs. placebo after one year (-7.5% vs. 5.3%, p(less than)0.0001)(7) >>

Notes to Editors:

(X)= Xenical European label

About Xenical(R) (orlistat 120 mg)

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