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New Data Show Pfizer's Axitinib Prolonged Overall Survival in,Advanced Pancreatic Cancer When Combined with Standard of Care,Chemotherapy

y development at Pfizer. "These exciting data contribute to an emerging body of research indicating the benefit that oral selective inhibitors of VEGF receptors, like axitinib, may provide to patients. We have plans to further explore axitinib in advanced pancreatic cancer as part of a Phase III program and are continuing to evaluate axitinib across multiple other tumor types."

The most common adverse events in trials of axitinib as a single agent included fatigue, proteinurea, stomatitis/mucositis, hypertension and diarrhea. When studied in combination with myelosuppressive chemotherapies, the most common adverse events included neutropenia, diarrhea, fatigue, stomatitis and hypertension. The complete adverse event profile of axitinib is not yet known.

About Axitinib

Axitinib is an oral, selective inhibitor of VEGFR 1, 2, 3 (vascular endothelial growth factor receptors 1, 2 and 3), which has been shown to induce tumor regression as a single-agent and in combination with chemotherapy. Inhibiting VEGF binding plays a key role in anti-angiogenesis - or blocking blood vessel formation which starves tumors of the blood and nutrients needed for growth.

Axitinib is an investigational agent and has not yet been approved by the U.S. Food and Drug Administration or other global regulatory agencies.

For more information on Pfizer Oncology please visit www.pfizer.com.

DISCLOSURE NOTICE: The information contained in this release is as of June 4, 2007. Pfizer assumes no obligation to update any forward-looking statements contained in this release as the result of new information or future events or developments.

This release contains forward-looking information about a product in development, including its potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by regulatory authorities regardi
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