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New Data Show Pfizer's Axitinib Prolonged Overall Survival in,Advanced Pancreatic Cancer When Combined with Standard of Care,Chemotherapy

CHICAGO--(BUSINESS WIRE)--Jun 4, 2007 - Pfizer announced today that axitinib (AG-013736), an investigational oral, selective inhibitor of VEGFR 1, 2,3 (vascular endothelial growth factor receptors 1, 2, 3) combined with gemcitabine showed a trend towards prolonged overall survival (OS) in patients with advanced pancreatic cancer, compared with gemcitabine alone, according to preliminary data from a randomized Phase II trial.

These data were presented at the 43rd American Society of Clinical Oncology (ASCO) Annual Meeting this week, along with results from several other Phase II studies evaluating the efficacy and safety of axitinib in metastatic refractory thyroid, renal cell, non-small cell lung (NSCLC) and breast cancer.

"Pancreatic cancer continues to be one of the most life-threatening and difficult-to-treat solid tumors," said lead study investigator Jean-Philippe Spano, MD, PhD, Hospital La Piti-Salpetriere. "Seeing an agent with this level of activity and tolerability at this stage in development is encouraging news for patients. These findings suggest that axitinib has anti-tumor activity in advanced pancreatic cancer and provide the basis for a Phase III program to further evaluate the potential benefits of this agent in pancreatic cancer patients."

Advanced Pancreatic Cancer

Results from a randomized Phase II study of 103 previously untreated patients with advanced pancreatic cancer demonstrated median overall survival with axitinib in combination with gemcitabine of 6.9 months compared with 5.6 months with gemcitabine alone. Axitinib combined with gemcitabine reduced the risk of death - by 26 percent compared to gemcitabine alone (HR=0.74; CI 0.427 - 1.284).

Advanced Refractory Thyroid Cancer

The anti-tumor effects of single-agent axitinib in advanced refractory thyroid cancer were demonstrated in a single-arm, multi-center Phase II study of 60 patients who were iod
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