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New Data Show Early Non-Response to Antipsychotic Treatment May Be,Strong Predictor of Subsequent Non-Response for People with,Schizophrenia

n(iii), homelessness(iv), repeated relapses(v) and attempted suicide(vi). Current findings, which are based on post-hoc analyses, are consistent with independent research, suggesting drug effect seems to occur during the first two weeks of treatment(vii). However, additional research is still needed.

"These data are potentially very important in helping to establish the most cost-effective strategies for treating patients with schizophrenia," said Dr. John Kane, chairman of the department of psychiatry, neurology and neuroscience, The Zucker Hillside Hospital, Glen Oaks, New York and professor of psychiatry, Albert Einstein College of Medicine, Bronx, New York. "Furthermore, clinicians need better guidelines and predictors of treatment response in order to make informed treatment decisions. This is a further step in that direction."

Schizophrenia is a brain disorder characterized by acute episodes of delusions (false beliefs that cannot be corrected by reason) and hallucinations (usually in the form of "hearing" voices)(viii), known as positive symptoms(ix). Patients can also experience negative symptoms - such as diminished emotion, general lack of interest and depressive signs and symptoms - that are often more difficult to treat than positive symptoms(x). More than two million American adults have schizophrenia(xi), and more than 100,000 new cases are reported each year. The World Health Organization estimates the annual cost of schizophrenia at $65 billion, including direct costs and lost productivity(xii).

"These data strongly advocate evaluating the potential benefit of antipsychotic medications earlier in treatment, so patients with schizophrenia can be spared from unnecessary increased exposure to a drug that is very unlikely to help them," said Dr. Cherri Miner, Lilly U.S. medical director, neuroscience. "Quick and effective symptom control is especially important for those patients with urgent needs and may increase the likelihood that
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