( /p> 4. Patients treated for 8 weeks wi...)New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension,Health

4. Patients treated for 8 weeks with a combination of the maximum dose 300mg of SPP100 and the maximum dose 320mg of Diovan [6] (ARB[7]) showed significant clinically relevant additional BP reductions of 4.2/3.2 mmHg and 4.4/2.5 mmHg compared to SPP100 and Diovan monotherapies respectively. This large study of 1,776 patients has produced a novel observation about the benefits of combining the maximum therapeutic doses of SPP100 and Diovan. There has only been one other small study combining the maximum recommended doses of an ACE-I and an ARB which also showed significant additional reductions in BP (Poster P - 418).

5. Patients treated with a combination of the maximum dose 300mg of SPP100 and the maximum dose 320mg of Diovan (ARB) showed significantly greater reductions in BP over an entire 24-hour period compared to SPP100 and Diovan monotherapies. This is particularly important during the night-time and early morning hours as many cardiovascular events occur between 2am and 6am. The results were consistent for both patients whose blood pressure naturally decreases at night (dippers) and for those whose blood pressure remains high at night (non-dippers) (Poster P - 452).

6. In a study of obese patients, who did not achieve BP control with the diuretic HCTZ alone, it was shown that patients treated for 8 weeks with a combination of SPP100 and HCTZ provided additional significant BP reductions. The combination also improved the number of patients achieving BP control compared to those receiving HCTZ alone. The combination of SPP100 and HCTZ also did not show the increased levels of fluid retention associated with the combination of amlodipine (CCB) and HCTZ (Poster P - 401)

The World Health Organization and the JNC-VII[8] estimate that 70% of hypertensive patients currently do not reach their blood pressure goals. As many patients with hypertension require more than one antihypertensive drug to control their elevated blood pressure, it i
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