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New Clinical Study Results Indicate Higher Early Virologic Response,with Celgosivir Combination Therapy in HCV Non-Responders

Data to be Presented April 15th at EASL Conference in Barcelona, Spain

VANCOUVER and SAN DIEGO, CA, April 11, 2007 /PRNewswire-FirstCall/ - MIGENIX Inc. , a clinical-stage developer of drugs for infectious diseases, has received new top-line results confirming the previously announced clinical results (November 6, 2006) indicating evidence of clinical benefit, safety and tolerability in a Phase II study using the oral alpha-glucosidase inhibitor, celgosivir (MX-3253), in combination with pegylated interferon and ribavirin.

In addition to confirming the overall conclusions of the original study analysis, retesting resulted in a larger percentage of patients achieving an Early Virologic Response(x) ("EVR") rate with celgosivir plus peginterferon alfa-2b and ribavirin (the "triple combination") as compared to treatment with peginterferon alfa-2b and ribavirin alone (the "control treatment") in patients with chronic hepatitis C virus genotype 1 infections who were characterized as non-responders to prior therapy with optimized pegylated interferon plus ribavirin, achieving:

    -   42% (5/12) EVR with the celgosivir triple combination arm compared to

        10% (1/10) EVR in the control treatment arm. This compares with 33%

        (4/12) EVR (triple combination) vs 10% (1/10) (control treatment) in

        the original study results. (x) EVR = 2 log(10) or greater

        HCV viral load reduction at 12 weeks.


    -   1.63 log(10) (triple combination) mean HCV viral load reduction

        ("VLR") compared to a 0.92 log(10) VLR (control treatment). This

        compares with a 1.2 log(10) VLR (triple combination) vs a 0.4 log(10)

        VLR (control treatment) in the original study results.


    -   a more rapid onset of treatment effect as measured by VLR within the

        first 2 weeks of therapy in the triple combination as compared to the

        control treatment.

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