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New Analysis of Data from WHI Provides Reassurance With Respect to,Coronary Heart Disease For Newly Menopausal Women Considering,Hormone Therapy

or years since menopause when therapy was initiated."

The findings reported in this publication are based on prespecified analyses of data from the WHI, a large-scale study sponsored by the National Institutes of Health that was designed to evaluate hormone therapy, dietary modification, calcium and vitamin D as preventive therapies for menopausal women. The hormone therapy arms were designed to assess select long-term risks and benefits of hormone therapy. The WHI studied conjugated estrogens (0.625 mg) (PREMARIN(R) [conjugated estrogens tablets, USP]) and oral conjugated estrogens (0.625 mg) combined with medroxyprogesterone acetate (2.5 mg) (PREMPRO(R) [conjugated estrogens/medroxyprogesterone acetate tablets]). PREMARIN and PREMPRO are the most widely prescribed hormone therapy products in the United States and offer significant clinical experience and the largest safety database available among hormone therapy products, providing extensive information to assist health care professionals in making appropriate treatment recommendations.

The absolute risk for cardiovascular disease associated with hormone therapy use depends on the background rate, which increases with various risk factors, including age, personal health history and family history, among others. For most early menopausal women, the absolute risk of cardiovascular disease is low. Current hormone therapy labeling includes a warning about the risks of cardiovascular disease, and advises against using hormone therapy for the prevention of cardiovascular disease.

Wyeth continues to support the use of hormone therapy and recommends that it be used at the lowest effective dose for the appropriate duration consistent with treatment goals and risks for the individual woman. Hormone therapy is not appropriate for all women. Women experiencing menopausal symptoms are encouraged to speak with their health care professionals to determine whether hormone therapy might be the right treatmen
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