Navigation Links
Neurogen Proprietary Insomnia Compound Data for Two Studies,Presented at Associated Professional Sleep Societies Annual Meeting

eep had been significantly more refreshing than did the placebo group. At 1, 3, and 10mg, subjects felt alert and more than 87% of subjects considered their ability to concentrate as "very good" or "excellent" the morning following dosing, which was similar to the placebo group.

In this study, NG2-73 was generally well tolerated with adverse events (e.g. somnolence) attributable to the pharmacological action of the drug. There were no deaths, or drug-related serious adverse events or discontinuations, and no clinically important changes in safety laboratory reports, vital signs or electrocardiograms (ECGs).

In this study, NG2-73 was shown to be a potent sedative hypnotic which significantly reduced LPS at all doses tested, which was supported by subjective responses indicating rapid sSL. Most subjects expressed good concentration, alertness, and feeling refreshed the next morning. In this study, NG2-73 was also generally well-tolerated.

"Pharmacokinetic-Pharmacodynamic Effects of NG2-73, a Novel GABA(A) Agonist, and Zolpidem" (Phase 1)

NG2-73 is a GABA(A) receptor partial agonist which has preference for the alpha-3 subunit. In vivo animal experiments suggest that NG2-73 will have an improved side effect profile compared to zolpidem based on ethanol interaction and on assessments of learning and memory at equipotent hypnotic doses. The objectives of this study were to evaluate the relationship of dose, plasma concentration, and time to the pharmacokinetics (PK) and pharmacodynamics (PD) of NG2-73 at doses of 1, 3, 5, and 10 mg and zolpidem 10 mg versus placebo in healthy subjects.

This was a single-center, randomized, double-blind, placebo-controlled, six-way crossover study of single oral doses of NG2-73 administered to 19 healthy volunteers. Safety and tolerability were assessed, and kinetic-dynamic relationships were determined using plasma concentrations and multiple measures of PD including a visual analog scale of sedation (V
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Neurogen Announces Positive Results for Proprietary Insomnia Drug in Two Chronic Insomnia Clinical Trials
2. Neurogen Proprietary Insomnia Compound Data Presented at Associated Professional Sleep Societies Annual Meeting
3. Neurogen Proprietary Insomnia Compound Data Presented at American Psychiatric Association Annual Meeting
4. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
5. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
6. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
7. Cytogen Reports Publication Validating the Utility of its Proprietary ProChart Database
8. Seattle Genetics Highlights Data on its Proprietary Antibody-Drug Conjugate Technology at AACR
9. Helix BioMedix to Discuss Potential of Its Proprietary Peptides at the BIO International Convention
10. Integrated Biopharmas Proprietary Vaccine Technology Achieves Strong Positive Results
11. Integrated BioPharmas Proprietary Vaccine Technology Achieves Strong Positive Results
Post Your Comments:
(Date:5/19/2013)... ORLANDO, Fla. , May 19, 2013 /PRNewswire/ ... power and low temperature radiofrequency (RF) energy is ... and eliminates or reduces the need for medication ... long-term assessment presented today at the Digestive Disease ... Orlando, Florida . ...
(Date:5/18/2013)... 18, 2013 Although colonoscopy exams prevent many ... most sensitive method for detecting colorectal cancers 2 , ... cases 3 . EndoChoice ® Inc. today unveiled ... improves the accuracy of this procedure and greatly reduces ... be discussing these clinical trial results and featuring the ...
(Date:5/18/2013)... , May 18, 2013 The ... , Occupy Psychiatry , and ... health care, announces a social media campaign showcasing ... traditional psychiatric model, which focuses on pathology and ... coincides with the American Psychiatric Association,s (APA) rollout ...
Breaking Medicine Technology:Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 2Stretta Procedure for GERD: Successful 10 Year Follow-Up Data Presented at Digestive Disease Week--Sustained Improvement, Long-Term Efficacy 3New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 2New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 3New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3
... Mass.--(BUSINESS WIRE)--Apr 13, 2007 - Biogen Idec ... presented at the,Academy of Managed Care Pharmacy's ... beta-1a) is a cost-effective therapy in,multiple sclerosis ... Using a comprehensive analysis of medical and ...
... suggests how lithium works as a,therapeutic , LOS ... lithium, long the standard treatment for bipolar disorder,increases ... of patients with,the illness. , ,The research ... journal,Biological Psychiatry and is currently available online. , ...
Cached Medicine Technology:New One-Year Pharmacoeconomic Study Shows Avonex is Cost-Effective,Relative to Other Interferon Therapies for Multiple Sclerosis 2New One-Year Pharmacoeconomic Study Shows Avonex is Cost-Effective,Relative to Other Interferon Therapies for Multiple Sclerosis 3UCLA: Lithium Builds Gray Matter in Bipolar Brains, UCLA Study,Shows 2UCLA: Lithium Builds Gray Matter in Bipolar Brains, UCLA Study,Shows 3
(Date:5/19/2013)... 2013 The muscles in the human ... and one of the biggest and most significant nervous ... The peripheral system comprises of peripheral nerves that reside ... nerves ensure that the limbs and hands, as well ... nerves get damaged due to trauma or physical injury, ...
(Date:5/19/2013)... 6Webs.com is the leader in reviews ... are considering an alarm system can do a comparison ... security system providers online at 6Webs.com. Just recently finishing ... home security system companies, 6Webs.com currently is announcing ... home security companies before ranking the home security system ...
(Date:5/19/2013)... The Pradaxa lawyers at Bernstein Liebhard ... convened for hundreds of Pradaxa bleeding lawsuits ... U.S. District Court, Southern District of Illinois. According ... 14th, the Conference addressed the status of depositions and ... Conference that Defendants submitted a list of early trial ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 The Fat Loss ... weight loss secrets that help people get in shape, ... and body shape. The program also is a natural fat ... plans. Besides, the author of this fat loss diet program ... program, which can help people keep body fat off long-term. ...
(Date:5/19/2013)... May 19, 2013 Exciting new Skin ... is reintroducing a great practice known through the ages ... known as dry body brushing, has so many benefits ... of Sublime Beauty®. "We love that circulation and lymphatic ... largest organ, the skin, is supported through Skin Brushing." ...
Breaking Medicine News(10 mins):Health News:Ultimate Neuropathy Support System Launched by Neuracel - Reaching New Heights in Herbal Medication for Peripheral Neuropathy 2Health News:Top Rated DIY Home Security System Companies Published by 6Webs.com 2Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 2Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 3Health News:Weight Loss Secrets | How “The Fat Loss Code” Helps People Gain A Healthy Life And Get In Shape - Health Review 2Health News:Exciting New Skin Brushes at Sublime Beauty® Bring Health and Beauty Benefits; Celebrities and Models Know the Secret 2
... The Body By Milk campaign -- famous for,putting white ... up with the,five-time GRAMMY(R)-Award winning and multi-platinum selling artist, Usher, ... the Body By,Milk got noise? music video program. , ... give 20 lucky teens the chance to flex their,creative muscle ...
... Still reeling from the current economic crisis in this country, ... look at spending. As experienced by the incomparable Dr. ... a recent shift in choices reveals a more discerning clientele, ... maintenance regime-even among his most recognized, celebrated & well-to-do patients. ...
... , , PRINCETON, N.J., Dec. 16 ... state, providing more than 113,000 full-time jobs, $7 billion in employee ... the New Jersey Hospitals 2008 Economic Impact Report. , ... for their societal contributions, including $1.3 billion in annual charity care ...
... most wonderful time of year, but when it comes to waistlines, it ... in commercial grade water filtration systems, offers several products for consumers that ... ... Ill. (Business Wire EON) December 16, 2008 -- "It is easy ...
... VA Medical Center , , ... nation,s premier providers of full lifecycle services for electrical and ... United States Army Corps of Engineers to perform a multi-million ... Medical Center (VAMC) in Atlanta, Georgia. , ...
... U.S. Preventive Medicine, the leader in disease prevention services, ... Majority Leader Tom Daschle (D-SD) to head the U.S. Department ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080506/NETU129LOGO ) , ... for Secretary of this vitally important agency, particularly at this ...
Cached Medicine News:Health News:Usher Teams With Body By Milk to Give Teens Once-in-a-Lifetime Opportunity 2Health News:Usher Teams With Body By Milk to Give Teens Once-in-a-Lifetime Opportunity 3Health News:Budget-Beauty for the Rich & Famous 2Health News:Budget-Beauty for the Rich & Famous 3Health News:Report: Hospitals Pump $18 Billion Into N.J. Economy 2Health News: Drinking Lots of Water Can Help Keep Holiday Weight Gain at Bay : Everpure Water Filtration Products Offer Festive Ways to Stay Healthy This Season 2Health News:M.C. Dean, Inc. Awarded Contract for Electrical Services at Atlanta VA Medical Center 2Health News:U.S. Preventive Medicine Praises Selection of Tom Daschle to Serve as Secretary of Health and Human Services 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: