Navigation Links
Neurogen Proprietary Insomnia Compound Data for Two Studies,Presented at Associated Professional Sleep Societies Annual Meeting

BRANFORD, Conn.--(BUSINESS WIRE)--Jun 13, 2007 - Neurogen Corporation (Nasdaq: NRGN) today announced that data from previous Phase 1 and Phase 2a clinical studies for NG2-73, the Company's lead compound for the treatment of insomnia, were presented in two sessions at the SLEEP 2007 Annual Meeting of the Associated Professional Sleep Societies (APSS) in Minneapolis, Minnesota. Two Phase 2b clinical studies with NG2-73 in chronic insomnia patients are currently being conducted by the Company. Data presented at the APSS meeting today includes the following:

"Effects of NG2-73 on Sleep Onset, Quality and Next Day Function in a Transient Insomnia Study" (Phase 2a)

NG2-73 is a partial agonist with preference for GABA(A) receptors containing the alpha-3 subunit. This mechanism of action may provide an important alternative to existing therapeutics for insomnia.

This double-blind, placebo-controlled, multi-center, randomized trial evaluated the efficacy of four dose groups of NG2-73 versus placebo in reducing Latency to Persistent Sleep (LPS) in healthy adults in a sleep laboratory, single-night, polysomnographic model of transient insomnia. This model of transient insomnia used both first night adaptation and "phase-advance" to create insomnia in healthy subjects. Subjects completed questionnaires assessing sleep effects, sleep quality, and next day functioning. Safety was monitored as per usual practice. Three hundred and sixty nine adults, aged 24 - 63, with no self-reported sleep disorders, were enrolled.

LPS was significantly reduced, compared to placebo, at all doses of NG2-73, in a dose-dependent manner with mean LPS of 30.8 minutes for the placebo group, and 17.8, 10.6, 7.8, and 6.6 minutes for the 1, 3, 10, and 20 mg NG2-73 groups, respectively. Subjective sleep latency (sSL) was significantly reduced compared to placebo at all doses. All four NG2-73 treatment groups reported that their sl
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Neurogen Announces Positive Results for Proprietary Insomnia Drug in Two Chronic Insomnia Clinical Trials
2. Neurogen Proprietary Insomnia Compound Data Presented at Associated Professional Sleep Societies Annual Meeting
3. Neurogen Proprietary Insomnia Compound Data Presented at American Psychiatric Association Annual Meeting
4. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
5. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
6. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
7. Cytogen Reports Publication Validating the Utility of its Proprietary ProChart Database
8. Seattle Genetics Highlights Data on its Proprietary Antibody-Drug Conjugate Technology at AACR
9. Helix BioMedix to Discuss Potential of Its Proprietary Peptides at the BIO International Convention
10. Integrated Biopharmas Proprietary Vaccine Technology Achieves Strong Positive Results
11. Integrated BioPharmas Proprietary Vaccine Technology Achieves Strong Positive Results
Post Your Comments:
(Date:5/4/2015)... , May 4, 2015  NeuroSigma ® , Inc. ... today announced that results of an animal study of its Thin ... th by Mayo Clinic researchers at the 53 rd ... Chicago, Illinois . A copy of the ... . The study at Mayo Clinic was primarily ...
(Date:5/4/2015)... According to a new market ... Ureteroscope), Flexible (Colonoscope, Gastroscope), Visualization Systems (Monitors, HD Camera, ... - Global Forecasts to 2019 ", published by MarketsandMarkets, the ... by 2019 with a CAGR of around 7% during ... Browse   127   ma rket data T ...
(Date:5/4/2015)... 2015 Dynatronics Corporation (the "Company") (NASDAQ: ... rehabilitation and physical therapy products, announced today that ... approximately $4,000,000 in a private placement financing led ... affiliates (together with its affiliates, "Prettybrook"), a strategic ... The financing will provide Dynatronics with additional capital ...
Breaking Medicine Technology:NeuroSigma's Thin Film Nitinol Flow Diverting Stent Results Presented at the American Society of Neuroradiology Meeting 2NeuroSigma's Thin Film Nitinol Flow Diverting Stent Results Presented at the American Society of Neuroradiology Meeting 3NeuroSigma's Thin Film Nitinol Flow Diverting Stent Results Presented at the American Society of Neuroradiology Meeting 4The Medical Videoscope Market Worth $19.0 Billion by 2019 2The Medical Videoscope Market Worth $19.0 Billion by 2019 3The Medical Videoscope Market Worth $19.0 Billion by 2019 4The Medical Videoscope Market Worth $19.0 Billion by 2019 5Dynatronics Announces $4,000,000 Private Placement Led By Prettybrook Partners 2Dynatronics Announces $4,000,000 Private Placement Led By Prettybrook Partners 3Dynatronics Announces $4,000,000 Private Placement Led By Prettybrook Partners 4
... Tenn., Oct. 27 Cumberland Pharmaceuticals Inc. (Nasdaq: ... quarter 2009 financial results before the market opens on Tuesday, ... webcast will be held on Tuesday, November 10, 2009 at ... participate on the call, please dial 888-417-8462 (for U.S. callers) ...
... , DENVER, Oct. 27 A Denver ophthalmologist recently became ... lens during cataract surgery, raising the bar for patient care ... his patients. , Dr. Paul Cutarelli, director of Cutarelli Vision ... nanoFLEX lens in October in the eye of a 70-year-old ...
Cached Medicine Technology:Cumberland Pharmaceuticals to Announce Third Quarter 2009 Financial Results on November 10, 2009 2Denver-Ft. Collins Ophthalmologist First in Colorado to Implant nanoFLEX Lens 2Denver-Ft. Collins Ophthalmologist First in Colorado to Implant nanoFLEX Lens 3
(Date:5/4/2015)... LiveSchool ” was featured on NewsWatch as part of ... latest and coolest applications on the market for iOS, ... and technology expert, conducted the app review and shared ... students with good behavior. , Positive re-enforcement is more ... And the good people at LiveSchool have taken note ...
(Date:5/4/2015)... The Lymphoma Research Foundation (LRF) – ... innovative lymphoma research and serving the lymphoma community through ... patient services – is set to host its annual ... West Orange, NJ on June 1, 2015. Since 2010, ... programs through LRF. , This year, the Lymphoma Research ...
(Date:5/4/2015)... The opportunity for children to dream of a bright ... behind The Fairy Godmother Next Door, a new children’s picture ... , The inspiration for the enchanting story of a fairy ... desire to be a fairy godmother. , “My wish came ... neighbors’ children since they were born. We discuss fairies and ...
(Date:5/4/2015)... Angeles, CA (PRWEB) May 04, 2015 In ... Ty Smalley took his own life. In the wake of ... for the Silent, an organization that exposes the grim reality ... is also a platform for Kirk and Laura to share ... prevent their tragedy from happening to another family — a ...
(Date:5/4/2015)... Glendale, CA (PRWEB) May 04, 2015 ... intensify as baby boomers join the ranks of senior ... unprecedented demand on an already over-burdened healthcare system. Additionally, ... qualified staff to replace them. Per the U.S. Census ... is expected to increase 75% by 2050 while those ...
Breaking Medicine News(10 mins):Health News:An Application for Teachers to Reward Students with Good Behavior Was Featured on NewsWatch Television 2Health News:Lymphoma Research Foundation Set to Host Annual Ace Lymphoma Luncheon at Mayfair Farms in West Orange, NJ 2Health News:Introducing New Children’s Book The Fairy Godmother Next Door 2Health News:WWE Legend "Rowdy" Roddy Piper Teams Up with Stand for the Silent for Timely Anti-Bullying Campaign 2Health News:WWE Legend "Rowdy" Roddy Piper Teams Up with Stand for the Silent for Timely Anti-Bullying Campaign 3Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 2Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 3Health News:U.S. Healthcare Worker Shortage Escalating: Sterling Warns Medical Practitioners to Rapidly Reverse Low Employee Retention 4
... in many highly cited cancer publications to support the ... cancer is questionable, according to a study by researchers ... journal PLoS Computational Biology on October 20th ... animals or on cells living in test tubes due ...
... Steven Reinberg HealthDay Reporter , THURSDAY, Oct. 20 ... the front of food and beverage packages to make it ... nutritious a product really is, a new Institute of Medicine ... systems out there," said Ellen Wartella, chair of the IOM ...
... , THURSDAY, Oct. 20 (HealthDay News) -- There,s a ... person who takes his or her own life there are many ... federal report released Thursday. The analysis of 2008-09 data from ... of serious thoughts of suicide range from about 1 in 50 ...
... that men who experience persistently moderate or high levels of ... 50 percent higher mortality rate. In general, the researchers ... of stress people who self-reported that they had good ... better. Moderate drinkers also lived longer than non-drinkers. ...
... (HealthDay News) -- Researchers report that following surgery, people with ... blood clots known as deep vein thromboses and pulmonary embolisms. ... a deep vein in the thigh or leg -- it,s ... passengers on long-haul flights. DVTs can travel to the lungs ...
... honored recently by the Armenian American Health Professional Organization ... the United States and in Armenia. The award was ... University School of Medicine (BUSM) and president of Boston ... the department of urology at BUSM and chief of ...
Cached Medicine News:Health News:Food Nutrition Labels Must Be Made Simpler, Experts Say 2Health News:Food Nutrition Labels Must Be Made Simpler, Experts Say 3Health News:Suicide Rates Vary by Region: CDC 2Health News:High to moderate levels of stress lead to higher mortality rate 2Health News:Inflammatory Bowel Disease Tied to Higher Risk of Post-Op Blood Clots 2Health News:Physician honored for medical contributions in US and Armenia 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: