Navigation Links
Neurogen Proprietary Insomnia Compound Data Presented at American,Psychiatric Association Annual Meeting

BRANFORD, Conn.--(BUSINESS WIRE)--May 23, 2007 - Neurogen Corporation (Nasdaq: NRGN) today announced that data from previous Phase 1 and Phase 2a clinical studies for NG2-73, the Company's lead compound for the treatment of insomnia, were presented today at the American Psychiatric Association (APA) annual meeting in San Diego. Two Phase 2b clinical studies with NG2-73 in chronic insomnia patients are currently being conducted by the Company. Data presented at the APA meeting include the following abstracts:

--NG2-73, a Novel GABA(A) Partial Agonist, Rapidly Induced Sleep in a Transient Insomnia Study (Phase 2a)

NG2-73 is a partial GABA(A) agonist with preference for receptors containing the (alpha)3 subunit. Preclinical studies suggest that this compound has sedative hypnotic effects, supporting development as a potential treatment for insomnia.

This double-blind, placebo-controlled, randomized, multi-center study was designed to determine the effects of 1,3,10 and 20mg of NG2-73 compared to placebo on sleep onset as measured by Latency to Persistent Sleep (LPS) in healthy adults. The study design incorporated a single-night, polysomnography (PSG) model of transient insomnia using both first night sleep laboratory adaptation and "phase-advance" effects. Subjects were dosed in the sleep laboratory 2.5 hours prior to median habitual bedtime. "Lights off" and PSG recording started 30 minutes later. Safety was monitored by adverse event recording, physical exams, vital signs, electrocardiogram (ECG) and clinical laboratory tests. 369 healthy subjects aged 24-63 with no self-reported sleep disorders were enrolled.

LPS was statistically significantly reduced, compared to placebo, at all doses of NG2-73, and demonstrated a dose-response relationship. The mean times for LPS were 30.8 minutes for the Placebo group, and 17.8, 10.6, 7.8, and 6.6 minutes for the 1, 3, 10, and 20 mg NG2-73 groups, resp
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Neurogen Announces Positive Results for Proprietary Insomnia Drug in Two Chronic Insomnia Clinical Trials
2. Neurogen Proprietary Insomnia Compound Data for Two Studies Presented at Associated Professional Sleep Societies Annual Meeting
3. Neurogen Proprietary Insomnia Compound Data Presented at Associated Professional Sleep Societies Annual Meeting
4. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
5. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
6. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
7. Cytogen Reports Publication Validating the Utility of its Proprietary ProChart Database
8. Seattle Genetics Highlights Data on its Proprietary Antibody-Drug Conjugate Technology at AACR
9. Helix BioMedix to Discuss Potential of Its Proprietary Peptides at the BIO International Convention
10. Integrated Biopharmas Proprietary Vaccine Technology Achieves Strong Positive Results
11. Integrated BioPharmas Proprietary Vaccine Technology Achieves Strong Positive Results
Post Your Comments:
(Date:7/23/2014)... July 23, 2014 PositiveID Corp. (OTCQB: PSID), ... , is an emerging player in the bio-threat ... bio-threat detection and rapid medical testing. The Company,s ... Bio-agent Autonomous Networked Detector), was developed under contract ... Science & Technology directorate, and $30 million of ...
(Date:7/23/2014)... PLYMOUTH MEETING, Pa. , July 23, ... MKT: INO) today announced successful results from ... of VGX-3100 in women with biopsy-proven cervical ... papillomavirus (HPV) types 16 or 18. Treatment ... histopathological regression of CIN2/3 to CIN1 or ...
(Date:7/23/2014)... , July 23, 2014  Nearly 8,000 attendees ... for Cardinal Health,s annual Retail Business Conference (RBC), taking ... Convention Center. This year,s event encourages pharmacists to "Lead ... their communities and for their future. ... owners to network with their peers and learn new ...
Breaking Medicine Technology:PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 2Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 3Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 4Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 5Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 2Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 3Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 4Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 5Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 6
... BIRMINGHAM, Ala., March 10, 2011 PNP ... from research conducted at Southern Research Institute and The ... that several major objectives have been reached in the ... for the treatment of cancer. "A number ...
... InstaCare Corp. (OTC Bulletin Board: ISCR ), ... the chronically ill, a leading fulfillment provider of direct to ... pending cell phone centric e -health products and technologies, ... pharmaceutical e-detailing Mobile Health Media System, known as ...
Cached Medicine Technology:PNP Therapeutics Meets Important Financial and Regulatory Objectives in Development of New Cancer Therapies 2InstaCare Announces Ready for Market MD@Detail Mobile Health Media System for Pharmaceutical e-Detailing 2InstaCare Announces Ready for Market MD@Detail Mobile Health Media System for Pharmaceutical e-Detailing 3
(Date:7/23/2014)... Texas Physical Therapy Specialists (TexPTS) is proud to ... Liberty Hill, Parmer, Balcones, and Georgetown clinics have received ... Certified Specialist (OCS) or Sports Certified Specialist ... Tony Lauretta, PT, DPT, OCS, Jason Brown, PT, DPT, ... DPT, OCS, and Mary Grimberg, PT, DPT, OCS received ...
(Date:7/23/2014)... the likelihood of forming false memories, according to research ... the Association for Psychological Science. , In a study ... University of California, Irvine and colleagues, sleep-deprived people who ... read false information about the photos were more likely ... than were those who got a full night,s sleep. ...
(Date:7/23/2014)... CarePoint Health is proud to announce ... Jersey to receive the da Vinci® Xi™ Surgical System, ... da Vinci series. This 4th generation robotic platform is ... innovation. The intuitive da Vinci Xi has broad capabilities ... minimally invasive and complex surgical procedures. The acquisition of ...
(Date:7/23/2014)... The North American market was valued at $985.4 million ... CAGR of 10.79%, to reach $1,801.1 million by 2018. Organobromines ... North American Bromine Market report defines and segments the bromine ... Browse through the TOC of the North American Bromine Market ... This also provides a glimpse of the segmentation in the ...
(Date:7/23/2014)... Recently, Agebc.com has launched its new ... is announcing a promotion of wedding dresses. According to ... at the end of this month. , The beautiful ... like A-line, mermaid, ball-gown, empire, and more. Agebc.com is ... special-occasion dresses for women, and the company is devoted ...
Breaking Medicine News(10 mins):Health News:Texas Physical Therapy Specialists Congratulates New Board Certified Specialists 2Health News:Texas Physical Therapy Specialists Congratulates New Board Certified Specialists 3Health News:Sleep deprivation may increase susceptibility to false memories 2Health News:CarePoint Health is First in New Jersey to Receive Newest Surgical Robot Platform 2Health News:CarePoint Health is First in New Jersey to Receive Newest Surgical Robot Platform 3Health News:CarePoint Health is First in New Jersey to Receive Newest Surgical Robot Platform 4Health News:North America Bromine Market is Expected to Reach $1801.1 million in 2018 - New Report by MicroMarket Monitor 2Health News:North America Bromine Market is Expected to Reach $1801.1 million in 2018 - New Report by MicroMarket Monitor 3Health News:North America Bromine Market is Expected to Reach $1801.1 million in 2018 - New Report by MicroMarket Monitor 4Health News:Agebc.com Launched Its New Collection of Wedding Dresses 2
... Bird, a molecular geneticist at the University of Edinburgh, Scotland, ... of a protein called Uqcrc1 in the brains of mouse ... which are the powerhouses of the cells to work overtime. ... mitochondrial gene has been linked to Rett Syndrome. The co-author ...
... that the male survivors of childhood sexual abuse ... understood// many health care practitioners as well as ... male and female childhood sexual survivors usually exhibit ... encounters with health care professionals, there are gender ...
... that New Orleans seems to be going throuogh a ... intensity rarely seen in the US. ,Suicide ... struck, 10 months ago. To make matters worse the ... the police department to deal with the large number ...
... University and the Celiac Sprue Research Foundation have claimed ... celiac sprue// that is an inherited inflammatory disorder of ... around the world. The two research studies that have ... Biology have opened the way for clinical testing with ...
... Cadbury Ireland had on the 23rd June recalled almost ... move because there are fears// that those bars may ... the company has said that there were minute traces ... levels that stipulated by the scientific standards for any ...
... to use a protein that has been originally isolated from ... genetically// modified technology. ,The parent company, Unilever, have ... ice creams that are of low-calorie, and low fat. They ... newer versions of their best selling products like the Cornetto, ...
Cached Medicine News:Health News:Researchers Have Linked Rett Syndrome to Mitochondrial Gene 2Health News:Researchers Have Linked Rett Syndrome to Mitochondrial Gene 3Health News:Sexually Abused Males Found Struggling In heir relations with Healthcare Providers 2Health News:Scientists Discover Non-dietary Therapy For Celiac Diseases 2Health News:Wall's To Develop Low-fat Ice-cream Using Fish Blood 2
Thermal Cautery, Sterile Single-Use Units for Vasectomy. Burns at approximately 1200C (2200 F). Integrated unit includes handle, vasectomy tip, & AA batteries. Box of 10 units. Discounts on 2 or more...
Li Brand™ Ringed Forceps. ("fixation clamp") For NSV and other procedures. Ring diameter approximately 3.5 mm. Manufactured exclusively for AMI to exacting specifications by a German company....
... users of "completely-in-the-canal" (CIC) instruments of ... ,Impressions of your ears are required. ... the ear are distributed via our ... These providers include audiologists and hearing ...
... bronchoscopy: The HF-compatible V series from Pentax, ... bronchoscopes are measured., ,The HF-compatible series ... FB-19TV, FB-18V and FB-15V models along with ... FB-8V, offer much better image quality thanks ...
Medicine Products: