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Neuroblastoma Expert Reviews Progress and Challenges in Fighting,Difficult Pediatric Cancer

tyrosine kinase inhibitors that interrupt a critical step in the tumor's growth process.

"These approaches are targeted therapies -- aimed in highly selective ways at cancer cells, but sparing healthy cells," said Maris. "But in order to best guide us to the most appropriate treatments, we need greater understanding of the abnormal biological events that give rise to neuroblastoma." One crucial technique for identifying biological pathways is through studies of the gene mutations and variations involved in different types of neuroblastoma, and Maris's team is calling on the sophisticated gene-hunting facilities at the new Center for Applied Genomics at Children's Hospital to advance that knowledge.

"Our goal is to match the most appropriate treatment with precise molecular targets in biological pathways, so we can intervene to stop neuroblastoma in its tracks," said Maris.

Support for the paper was provided in part by the National Institutes of Health, the Children's Oncology Group, and a variety of private foundations and organizations. In addition to his position at Children's Hospital, Maris is on the faculty of the University of Pennsylvania School of Medicine. Maris's co-authors were Michael D. Hogarty, M.D., of The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine; Rochelle Bagatell, M.D., of the University of Arizona Health Sciences Center and Steele Children's Research Center of Tucson, Ariz.; and Susan L. Cohn, M.D., of Comer Children's Hospital and the University of Chicago.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide.
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