Navigation Links
Nereus Pharmaceuticals to Present Data at the American Association,for Cancer Research 2007 Annual Meeting

Mini-symposium

#4948: NPI-1387 decreases IKKa kinase activity, inhibits NF-kB activation and induces apoptosis in hematological and solid tumor cell lines

Ta-Hsiang Chao, Ana Maria Barral, Gordafaried Deyanat-Yazdi, Venkat Macherla, Barbara Potts, Young-Ger Suh, Kenneth Lloyd, Michael Palladino, Saskia Neuteboom. Nereus Pharmaceuticals, San Diego, CA, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

Nereus is conducting two Phase I clinical trials of NPI-0052, a novel, small molecule proteasome inhibitor. One study is in patients with solid tumors and lymphomas and the second study is in patients with relapsed/refractory multiple myeloma. NPI-0052 was discovered from the fermentation broth of Salinispora tropica, a new marine actinomycete identified in sediment from the ocean floor. The compound is a potent and broad inhibitor of human proteasome activity, a high-interest drug target for pharmaceutical companies after bortezomib was successfully developed to treat multiple myeloma and mantle cell lymphoma. Preclinical studies indicate NPI-0052 is active against myeloma cells from patients who are resistant to bortezomib, steroid therapy, thalidomide and lenalidomide. It also appears to have a preferable pre-clinical safety profile compared to bortezomib and has shown broad efficacy in a wide range of animal models for both hematological malignancies and solid tumors.

Nereus is conducting an open label, single-agent Phase I study of NPI-2358 in patients with solid tumors and lymphomas. NPI-2358 is one of over 200 analogues that were prepared following the discovery of Halimide from a marine fungus. In preclinical models of cancer, including breast, sarcoma, colon and prostate, NPI-2358 demonstrated potent and selective anti-tumor effects in combination as well as single-agent efficacy in a number of orthotopic models. NPI-2358 interacts with soluble beta-tubulin and prevents the polymerization of tubulin without a
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
4. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
5. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
6. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
7. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
8. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
9. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
10. Cyclacel Pharmaceuticals Announces Results of Phase II Seliciclib Combination Studies
11. Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
Post Your Comments:
(Date:8/22/2014)... , Aug. 22, 2014 Today, the ... modify the religious "accommodation" but still require religious ... have an abortifacient effect, including Plan B (the ... pill"). The Obama Administration also announced that it ... held, for-profit corporations. The regulations issued ...
(Date:8/22/2014)... Aug. 22, 2014  Dr. Mark Rasak , ... Diamond Lifetime Achievement Award in the field of Medicine ... Cardiovascular Clinical Associates. Dr. Rasak has over ... major aspects of the business; overseeing the daily operations; ... coronary intervention. In addition, he is an honored Fellow ...
(Date:8/22/2014)... ., Aug. 22, 2014  Research presented at the 29 ... being developed by Hera Therapeutics Inc. combats three types of ... all cervical cancer. When tested in several cultured ... and HPV-11 cells, according to Louise T. Chow , ... findings at the Seattle conference. The ...
Breaking Medicine Technology:Liberty Institute: Government "Accommodation" Still Requires Employers To Facilitate Coverage Of Abortifacient Drugs 2Dr. Mark Rasak, MD is recognized by Continental Who's Who with the Diamond Lifetime Achievement Award 2Study shows Hera Therapeutics experimental compound shuts down human papillomavirus that causes most cervical cancer 2
(Date:8/22/2014)... 11 (BIM) deletion in advanced non-small cell lung ... survival (PFS) in epidermal growth factor receptor (EGFR) ... patients. Also, BIM deletion independently predicts overall survival ... protein can activate the programmed cell death also ... deletion has been detected in 12.8% of the ...
(Date:8/22/2014)... 2014 Paying tuition and other related ... coming year for four nurse educators pursuing advanced degrees, ... for Nursing Foundation for Nursing Education . This year’s ... $10,000 more than in 2013, thanks to these named ... Elizabeth Isaac Marcil Endowment Funds, both donated by Kathy ...
(Date:8/22/2014)... Eagerly embracing intended parents around the globe, ... offers the top male infertility programs — run by ... network of IVFinMexico.com continues to shape modern ... female and male infertility, advanced research and education. , ... eminently set by company CEO and Founder Tolga Umar ...
(Date:8/22/2014)... effort to sterilize feral cats reduced the number of felines ... new study reveals. "We investigated whether we ever could ... Dr. Julie Levy, a professor of shelter medicine at the ... university news release. "Neutering a few cats here ... we wanted to pick a focused area and throw all ...
(Date:8/22/2014)... Oklahoma (PRWEB) August 22, 2014 A national ... moving into new offices with room to grow. , Headquarters ... relocating to a 60,000-square-foot office building at 8516 N.W. Expressway ... – named one of the Oklahoma’s best places to work ... staff. The company has hired 120 in the past two ...
Breaking Medicine News(10 mins):Health News:Deletion predicts survival in advanced non-small cell lung cancer 2Health News:NLN Foundation for Nursing Education Announces 2014 Faculty Scholarship Awards 2Health News:NLN Foundation for Nursing Education Announces 2014 Faculty Scholarship Awards 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 2Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 3Health News:Mexico Now Offers Top Program for Couples Suffering from Male Infertility 4Health News:Neutering Project Curbed Feral Cat Population 2Health News:Fast-growing 180 Medical Moves Into New 60,000-square-foot Office in Oklahoma City 2
... The Long Island Patient Information eXchange (LIPIX) went ... for providers accessing LIPIX online systems. LIPIX realizes ... health organizations through its HIE, but also understands that ... proper assurance that the information will be protected. ...
... obesity more likely in kids who watch 2 hours-plus a day ... front of the TV might seem like an easy way to ... dinner, but too much TV time is definitely not a good ... the risk of childhood obesity, the likelihood of behavioral problems also ...
... award-winning actress, author and comedienne who is now the ... describe her amazement at her new job at a ... http://www.newscom.com/cgi-bin/prnh/20080917/NPCLOGO ) Drescher was instrumental in ... Awareness Act. She now helps spend its money by ...
... toxin in leg bones are tied to poorer scores on cognitive ... levels of environmental lead earlier in the life span may be ... new study finds. , The Harvard study shows that women aged ... (indicating a recent exposure to the metal) or bones (an indication ...
... Conn awarded $15,000 for envisioning the ,home of the ... At the Embedded Systems Conference (ESC) Silicon Valley ... winner of the Microsoft Windows Embedded SPARKs Will Fly ... and innovation among the embedded hobbyist and academic communities. ...
... reporting that has enhanced public understanding of biomedical ... Research (FBR) announced today it is accepting entries ... Awards. The awards, named after FBR,s late ... whose reporting has enhanced public understanding of how ...
Cached Medicine News:Health News:LIPIX Protects Access to Electronic Health Information With the Anakam Identity Suite(R) 2Health News:LIPIX Protects Access to Electronic Health Information With the Anakam Identity Suite(R) 3Health News:TV Time May Not Be Benign 2Health News:TV Time May Not Be Benign 3Health News:Can Cancer Be Funny? Fran Drescher, Award-Winning Actress and U.S. Special Envoy for Women's Health Will Speak at the National Press Club on April 14 2Health News:Accumulated Lead May Affect Older Women's Brains 2Health News:Microsoft Windows Embedded Announces Winner of SPARKs Will Fly Developer Contest 2Health News:Foundation for Biomedical Research Announces Michael E. DeBakey Journalism Awards 2
... stabilized hyaluronic acid-based dermal filler and ... the U.S. market. It is indicated ... facial wrinkles and folds (such as ... under the skins surface to replenish ...
... Response is a whole blood ... be used at the point-of-care. ... screen and data management features, ... options. QC and operator lockout ...
... clinically proven aminophylline directly to the area ... reduction with the aminophylline containing cream has ... increase in the firmness of the thighs. ... skin where it causes the body fat ...
... is a unique, non-invasive way of ... of cellulite and improving overall skin ... was used to rehabilitate scars, burns ... surprising side-affect was discovered - the ...
Medicine Products: