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Nereus Pharmaceuticals to Present Data at the American Association,for Cancer Research 2007 Annual Meeting

SAN DIEGO, April 09, 2007 /PRNewswire/ -- Nereus Pharmaceuticals, Inc., a pioneer in drug discovery and development from marine microbial sources, and its collaborators will present clinical and preclinical study results involving its cancer drug candidates at the American Association for Cancer Research Annual Meeting in Los Angeles April 14-18. Four posters and two minisymposia will highlight the novel mechanisms and anti-tumor activity in several tumor models for three Nereus compounds: the small molecule proteasome inhibitor NPI-0052, the tumor vascular disrupting agent (VDA) NPI-2358, and a new preclinical candidate NPI-1387, a highly selective, small molecule IKK modulator. Nereus will also present preliminary data from its Phase I dose escalation trial of NPI-2358 in patients with solid tumors and lymphoma.

In addition to the Company's single agent studies, Nereus collaborators from the University of Texas M.D. Anderson Cancer Center will describe research demonstrating markedly enhanced potency and apoptosis in human leukemia cells treated with NPI-0052 and various histone deacetylase (HDAC) inhibitors.

Nereus researchers and collaborators will make the following presentations at AACR:

Sunday, April 15, 2007

#1445: Sensitization of B-NHL resistant tumor cells overexpressing Bcl-xL to TRAIL-induced apoptosis by the novel proteasome inhibitor Salinosporamide A (NPI-0052)

Eriko Suzuki, Michael Palladino, Genhong Chen, Benjamin Bonavida. David Geffen School of Medicine at UCLA, Los Angeles, CA, Nereus Pharmaceuticals, San Diego, CA

#1453: Rituximab-mediated sensitization of resistant B-NHL cell lines to the proteasome inhibitor NPI-0052-induced apoptosis: pivotal role of PTEN induction and inhibition of Bcl-xL

Eriko Suzuki, Michael Palladino, Benjamin Bonavida. David Geffen School of Medicine at UCLA, Los Angeles, CA, Nereus Pharmaceuticals, San Diego, CA


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