Navigation Links
NIDA Study Identifies Genes That Might Help Some People Abstain,from Smoking

Findings Move Science Closer to Targeted, Improved Therapies

BETHESDA, Md., April 2, 2007--Scientists supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have for the first time identified genes that might increase a person's ability to abstain from smoking. The breakthrough research was conducted by Dr. George Uhl at NIDA's Intramural Research Program and a team led by Dr. Jed Rose at the Center for Nicotine and Smoking Cessation Research at Duke University Medical Center.

The study, published in the journal "BMC Genetics", available online April 2, brings researchers a step closer toward tailoring individualized drug therapy for addiction based on an individual's unique genetic make-up.

"This research marks the first time we've been able to identify genes involved in the ability to quit smoking," says NIDA Director Dr. Nora D. Volkow. "It marks a movement from identifying the genetics of addiction vulnerability to identifying the genetic basis of successful abstinence. This knowledge could impact the success rate of cessation programs by helping health care providers choose the most appropriate treatment based on individual differences."

Dr. George Uhl and his colleagues performed a genome wide analysis on the DNA of two types of nicotine dependent individuals, one that was able to successfully quit the cigarette smoking behavior and one that was not.

"We identified 221 genes that distinguished successful quitters from those who were unsuccessful," says Dr. Uhl. "We know the functions of about 187 of these genes, but 34 have functions that are unknown at present. We also found that at least 62 of the genes that we had previously identified as playing roles in dependence to other drugs also contribute to nicotine dependence."

Genes that harbor variants that contribute to both success in quitting smoking and in vulnerabil
'"/>




Page: 1 2 3

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
(Date:8/29/2014)... , Aug. 29, 2014 The Competitive ... regulatory and marketplace changes. CI leaders who adjust will ... In a new Best Practices, LLC study CI ... actionable insights, including: - Use secondary research ... primary research - Internal staff who are ...
(Date:8/29/2014)... , Aug. 29, 2014  A Boston ... multinational study on stent removability and preliminary long ... been published in the August issue of the ... study 1 is being conducted in 11 ... fully covered self-expanding metal stents (FCSEMS) after extended ...
(Date:8/29/2014)... Thoratec Corporation (NASDAQ: THOR ), ... to save, support and restore failing hearts, said today ... Global Healthcare Conference on Wednesday, September 10. ... Officer, will provide an update on the company, beginning ... Daylight Time).   A webcast of the ...
Breaking Medicine Technology:Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
... March 26, 2012   Sigma-Aldrich ® Corporation (Nasdaq: ... of Europe,s Top Employers by the Corporate Research ... business journalists, trade associations, researchers and international publishers ... acknowledgement.  Sigma-Aldrich is one of nine companies that ...
... -- Pennystocksinsiders.com (PSI) has issued insider trading reports and ... Atmel (NASDAQ: ATML), USG (NYSE: USG), Applied Materials (NASDAQ: ... and Key Energy Services (NYSE: KEG). ... report by clicking the link below, you may need ...
Cached Medicine Technology:CRF Institute Names Sigma-Aldrich Top Employer Europe 2012 2CRF Institute Names Sigma-Aldrich Top Employer Europe 2012 3Equity Research on Most Popular Searches: Atmel, USG, Applied Materials, Sprint Nextel, Galena Biopharma, and Key Energy Services 2Equity Research on Most Popular Searches: Atmel, USG, Applied Materials, Sprint Nextel, Galena Biopharma, and Key Energy Services 3
(Date:8/31/2014)... (PRWEB) August 31, 2014 Priya ... NutriGold , expressed concern over misinformation about weight-loss ... conflicting and, quite often, misleading information being propagated ... TV personalities are weighing in on the ... about vitamins, supplements, and especially weight-loss products and ...
(Date:8/31/2014)... Healthy Grid announced the impending release ... lollipops will use herbs to fight the bacteria that cause ... fight bacteria while stimulating saliva production. , “We're very excited ... of Healthy Grid. “Even though personal dental care is on ... little more prevention. Cavities are painful and expensive but these ...
(Date:8/31/2014)... Brook Forest Voices , audiobook producer and ... Short Stories of Wisdom and Kindness from Around the ... Jackson author, speaker, humanitarian and cultural economist. , In ... vast volume of meticulously handwritten notes taken while traveling ... behalf of Project C.U.R.E . Founded in 1987 ...
(Date:8/31/2014)... denervation seems to be more successful at reducing blood ... accessory renal arteries, according to research presented at ESC ... Dr Schmiedel said: "More than one billion people worldwide ... pressure (BP) greater than 140/90 mmHg. Up to 15% ... unable to reduce BP below 140/90 mmHg despite adhering ...
(Date:8/30/2014)... Local anaesthetic is as safe and effective for transcatheter ... results of the FRANCE 2 registry presented at ESC ... Dr Chopard said: "Numerous studies have shown that TAVI ... symptomatic aortic stenosis who are at very high risk ... number of TAVI procedures in France and around the ...
Breaking Medicine News(10 mins):Health News:New Reasons to Verify Label Claims on Weight-loss Products Before Buying 2Health News:New Reasons to Verify Label Claims on Weight-loss Products Before Buying 3Health News:Healthy Grid: Fight Cavities With Sweet Treats 2Health News:Healthy Grid: Fight Cavities With Sweet Treats 3Health News:Brook Forest Voices Announces End of Summer Release! Dr. James Jackson’s, “Simplicity & Sophistication” Audiobook 2Health News:Renal denervation more successful when it includes accessory arteries 2Health News:Local anesthetic for TAVI as safe and effective as general anesthetic 2
... 3 (HealthDay News) -- The impending extinction of various ... important buffer against the transmission of infectious disease, new ... U.S. National Science Foundation and National Institutes of Health,s ... Environmental Protection Agency, focused on how the loss of ...
... findings will be highly useful to the manufacturing industry ... toothpaste, cosmetics, pharmaceuticals and foodstuffs depends on an understanding ... The research just published in Nature ... of Physics and Astronomy, with collaborators at the University ...
... Nearly a quarter of Americans live in rural areas, which ... and suburban areas. Among the complex causes for this disparity ... areas and almost 4 out of 10 rural residents ... Finding the time, transportation, and financial resources for travel ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, ... can cut your risk for first-time stroke by 80 ... Association and the American Stroke Association. Also, as ... care, ER doctors are in a position to identify ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, Dec. ... Department of Health and Human Services (HHS) has announced its ... including making dents in rates of obesity, smoking and deaths ... People is to try to move the nation to better ...
... From hotel-style room service to massage therapy to magnificent ... a bid to gain market share, especially those in ... in the New England Journal of Medicine , ... hospital care, explaining that how we decide to value ...
Cached Medicine News:Health News:Species Extinctions May Spell Trouble for Human Health 2Health News:Smashing fluids: The physics of flow 2Health News:ALBERT EINSTEIN COLLEGE OF MEDICINE HELPS ADDRESS NEED FOR IMPROVED CANCER CARE IN RURAL AMERICA 2Health News:Lifestyle Key to Preventing Stroke, Guidelines Say 2Health News:U.S. Government Sets New Health Goals for 2020 2Health News:U.S. Government Sets New Health Goals for 2020 3Health News:Hospital perks: How much should hospitals be rewarded for the patient experience? 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: