Navigation Links
NCI Researchers Discover Genes That Are Turned on at High Levels in,Tumor-associated Blood Vessels of Mice and Humans

BETHESDA, Md., June 11, 2007--A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a tumor's blood supply without affecting the blood vessels of healthy tissues, overcoming one of the major concerns of current anticancer therapies targeted at blood vessel growth. The findings are published in the June 2007 issue of the journal "Cancer Cell".

"These results offer new insights into what is an important aspect of tumor development," said NCI Director John E. Niederhuber, M.D. "How blood vessels grow, intertwined with normal tissue in a tumor's microenvironment, is not just an area of scientific interest; it's a research field that is continuing to develop potentially potent and specific anticancer agents that cut off the tumor from a vital support system."

The growth of blood vessels, a process known as angiogenesis, is a normal process in the body that is essential for organ growth and repair. In many diseases, including most forms of cancer, this carefully regulated process becomes imbalanced, and normal blood vessel growth is redirected toward supplying nutrients and oxygen to feed diseased tissue, destroy normal tissues, and in the case of cancer, allow tumor cells to escape and travel to distant sites in the body. Researchers have tried to stop disease-related angiogenesis by identifying the molecules that stimulate blood vessel and developing new drugs to block their action. However, blocking angiogenesis requires a delicate balance between tumor and normal cells as most angiogenesis-related molecules are also critical for normal blood vessel growth in the body -- for example , during menstruation, pregnancy, or tissue repair. Thus, drugs that target critical angiogenesis molecules can cause a wide range of unintended si! de effects in healthy tissue.

The NCI research team, led by Brad St. Croix, Ph.D., head of the Tumor Angiogenesis Section at the NCI's Center for Cancer Research (CCR) in Frederick, Md., set out to discover the molecular differences between tumor-associated and normal angiogenesis to identify potential new drug targets. St. Croix and his colleagues focused on endothelial cells, which line the inner surface of blood vessels and are critical for new vascular growth.

The researchers chose to analyze endothelial cells derived from mouse liver, because the liver can be induced to sprout new blood vessels when regenerating itself following partial surgical removal. By comparing the gene expression profiles of endothelial cells from regenerating liver to those derived from tumor-bearing livers, the researchers found 13 distinct genes that were selectively overexpressed (turned on to a greater degree than other genes) during disease-related angiogenesis. Among the genes identified was CD276, a gene that encodes a protein located on the cell surface, as well as other known and previously undescribed genes.

To determine if the mouse findings were relevant to human cancers, the researchers then examined CD276 expression patterns in endothelial cells derived from cancer patients. They found that the CD276 protein was overexpressed in tumor-associated blood vessels from colon, lung, breast, esophageal and bladder cancers. In addition, the protein was also found to be frequently overexpressed by the tumor cells themselves, indicating that a suitable inhibitory molecule might be able to deliver a double blow -- one to the tumor cells themselves and the other to the blood vessels that feed them.

"These studies demonstrate that CD276 is overexpressed in the blood vessels of a variety of human cancers," says S t. Croix. "Therefore, it may be an important target for the development of new drugs that can selectively home in on blood vessels associated with disease."

For more information on this research and on the St. Croix laboratory, please go to <http://ccr.cancer.gov/Staff/staff.asp?profileid=6438>.

For more information about cancer, please visit the NCI website at <http://www.cancer.gov>, or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).

The National Institutes of Health (NIH) -- The Nation's Medical Research Agency -- includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit <http://www.nih.gov>.

###

U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH NIH News National Cancer Institute (NCI) <http://www.nci.nih.gov/>

Monday, June 11, 2007, 12:00 p.m. EDT CONTACT: NCI Office of Media Relations, 301-496-6641, ncipressofficers@mail.nih.gov>
--------------------------- REFERENCE: Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, and St. Croix B. June 11, 2007. "Cancer Cell", Vol. 11, Issue 6.

Researchers are from the Tumor Angiogenesis Section, Mouse Cancer Genetics Program, CCR, NCI, Frederick, Md. ---------------------------


'"/>




Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Researchers Discover Method for Identifying How Cancer Evades the Immune System
4. Researchers Discover Gene For Rare Skin Disorder
5. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
6. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
7. Dasatinib Shows High Early Response Rate as First Treatment for Chronic Myelogenous Leukemia, M. D. Anderson Researchers Report
8. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
9. Researchers Urge Caution in Using ESAs for Cancer-Related Anemia
10. Researchers Identify New Genetic Risk Factors for Type 2 Diabetes
11. Abbott Researchers Focus on New Cutting-Edge Approaches in the Fight Against Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... 8, 2016 Research and Markets has announced ... their offering. ... The global chromatography market to grow at a ... Market 2016-2020, has been prepared based on an in-depth market analysis with ... growth prospects over the coming years. The report also includes a discussion ...
(Date:12/8/2016)... , December 8, 2016 ... "Sugar-Based Excipients Market by Product (Actual Sugars, Sugar ... (Filler & Diluent, Tonicity Agents), Formulation (Oral, Topical, ... MarketsandMarkets, the market has witnessed healthy growth during ... at a CAGR of 4.3% between 2016 and ...
(Date:12/8/2016)... , Dec. 8, 2016  Agenovir Corporation, a ... novel antiviral therapeutics, today announced that it appointed ... officer and a member of the board of ... executive with a deep background in both founding ... founder of Agenovir, co-president of Chan Zuckerberg  Biohub ...
Breaking Medicine Technology:
(Date:12/8/2016)... ... December 08, 2016 , ... Russ DiGilio ... the first national #QuackGivesBack campaign which supported local breast cancer organizations during National ... Quack Gives Back initiative, and we’re very pleased with the participation ...
(Date:12/8/2016)... ... December 08, 2016 , ... With the increasing demand for dental ... Your Mouth?” (WIYM) campaign to inform dentists and patients about the safety issues related ... and prosthetic market in the U.S. is projected to reach $6.4 billion in 2018 ...
(Date:12/8/2016)... ... December 08, 2016 , ... Catalent Pharma Solutions, ... biologics and consumer health products, today announced that it had joined the Pharmaceutical ... a non-profit organization to unite pharmaceutical and healthcare companies that share a vision ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... Care Act. Dr. Botelho advocates for the mass media launching of story movements ... ongoing opportunities to share their unfortunate experiences; such a movement can generate the ...
(Date:12/8/2016)... ... December 08, 2016 , ... Peter Zipp Insurance, an ... around the greater Phoenix metropolitan region, is announcing a charity event to provide ... the Homeless Youth Connection is to promote community awareness of the ongoing needs ...
Breaking Medicine News(10 mins):