Navigation Links
Mymetics' HIV Vaccine Demonstrates First-Ever Production of,Neutralizing IgA Antibodies in Non-Human Primate Model

NYON, Switzerland, June 07, 2007 /PRNewswire-FirstCall/ -- Mymetics Corporation announced today analysis of results demonstrating that the Company's HIV vaccine elicited neutralizing IgA mucosal antibodies in a non-human primate model. Mucosal IgA antibodies are considered as a possible first line of defense against infection by HIV. The data were presented by Sylvain Fleury, Ph.D., Mymetics' Chief Scientific Officer, in an oral presentation titled, "Without Mucosal Adjuvant, Virosomes-gp41 Peptides from the MPR can Elicit Protective Mucosal IgA in Vaccinated Macaques," at the recent Keystone Symposium, HIV Vaccines: From Basic Research to Clinical Trials.

According to the findings, more than 90 percent of non-human primates vaccinated with virosomes expressing the HIV-1 gp41 peptide produced mucosal IgA antibodies in the genital and intestinal compartments. These mucosal antibodies were capable of preventing HIV transcytosis, a process by which HIV crosses the membrane epithelium of the mucosa, by 60 to 98 percent. When total IgA was purified for testing in standard neutralizing assays (TZMbl), the IgA antibodies also showed the ability to neutralize a primary HIV clade B virus (QH0692) known to be difficult to neutralize. Mucosal IgA produced against the HIV gp41 protein after vaccination was determined to be as good or better than the best anti-HIV neutralizing monoclonal antibodies (2F5, 4E10 and b12) currently on the market, when comparing the amount of antibodies required for neutralizing 50 percent of the viruses.

Mymetics' Dr. Fleury commented, "These results are extremely encouraging. We believe that, by using virosomes which target the mucosal compartment, we now have a means to elicit neutralizing IgA that can potentially work at low concentrations. Furthermore, virosomes do not require a mucosal adjuvant for triggering mucosal antibodies. This may cut the time to market since mucosal a
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Mymetics HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model
2. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
3. DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC
4. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
5. DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC
6. Vaccine Can Prevent Cervical Cancer and Precancerous Lesions
7. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
8. Based on Up to 6 Years of Follow-Up, Biovest Announces Favorable Interim Blinded Data for Fast-Tracked Pivotal Phase 3 Clinical Trial of BiovaxID Anti-Cancer Vaccine for Non-Hodgkins Lymphoma
9. HepaLifes PBS-1 Cells for Influenza Vaccine Production Prove Superior at International Conference
10. New Flu Vaccine from PepTcell Could Provide Immunity Against All Strains of Influenza Virus
11. Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur
Post Your Comments:
(Date:7/28/2015)... 2015  Nevro Corp. (NYSE: NVRO ), ... innovative evidence-based solutions for the treatment of chronic ... results in the Online First edition of ... of Anesthesiologists. The SENZA-RCT pivotal ... first to directly compare spinal cord stimulation (SCS) ...
(Date:7/28/2015)... , July 28, 2015  SeraCare Life ... diagnostics manufacturers, announced today at the American Association ... signed a licensing agreement with the University of ... Trisomy 21 (T21), Trisomy 18 (T18) and Trisomy ... component for creating "patient-like" reference materials for Non-Invasive ...
(Date:7/28/2015)... 28, 2015 According to the ... Type (Dermatology Treatment Devices, and Dermatology Diagnostic Devices [Imaging ... by Geography - Analysis and Forecast to 2019", The ... billion by 2019, at a CAGR of 10.4% from ... of Global Dermatology Devices Market for an in-depth analysis ...
Breaking Medicine Technology:Nevro Announces Publication of SENZA-RCT Results in Anesthesiology 2SeraCare Life Sciences Signs License Agreement with UCSF and Announces Early Access Program for Development of Aneuploidy Reference Materials 2SeraCare Life Sciences Signs License Agreement with UCSF and Announces Early Access Program for Development of Aneuploidy Reference Materials 3Global Dermatology Devices Market to be Worth $11.88 Billion by 2019 2Global Dermatology Devices Market to be Worth $11.88 Billion by 2019 3
... PROMUS(TM) Element(TM) Platinum Chromium StentNATICK, Mass., Feb. 3 ... announced the beginning of patient enrollment in the PLATINUM ... PROMUS(TM) Element(TM) Everolimus-Eluting Coronary Stent. The first U.S. ... of the Rockies in Loveland, Colorado by Thomas Downes, ...
... Adolescents and young adults who are heavy users ... have disrupted brain development, according to a new ... the brain that interconnect brain regions involved in ... The findings are of particular concern because adolescence ...
Cached Medicine Technology:Boston Scientific Begins Clinical Trial Enrollment for New Everolimus-Eluting Stent 2Boston Scientific Begins Clinical Trial Enrollment for New Everolimus-Eluting Stent 3Boston Scientific Begins Clinical Trial Enrollment for New Everolimus-Eluting Stent 4Boston Scientific Begins Clinical Trial Enrollment for New Everolimus-Eluting Stent 5Heavy Marijuana Use May Damage Developing Brain in Teens, Young Adults 2Heavy Marijuana Use May Damage Developing Brain in Teens, Young Adults 3
(Date:7/29/2015)... ... ... Today marks a significant achievement in bringing new monies into early stage ... by a group of experienced investors, has tapped into an investor community passionate about ... a part of the fund. The Sofia Fund II is now closed to ...
(Date:7/29/2015)... ... 2015 , ... July is National UV Awareness Month, and in honor of this month, Dr. ... to protect skin from the sun, as well as how to best treat existing sun ... the most common skin conditions in America. Many people do not protect their skin sufficiently ...
(Date:7/29/2015)... Madison, Wis. (PRWEB) , ... July 29, 2015 ... ... enrolled its first two patients in a Clinical Performance Study for the Invisiport ... includes 4.4 and 6 French catheter options, offers a less invasive, patient-friendly alternative ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... a “forward thinker.” Since the late 1970s, Dr. Cottrell has been making predictions ... book, The New Earth, documents many of these prognostications. He warns that extreme ...
(Date:7/29/2015)... ... July 29, 2015 , ... HealthPostures ( ... a partnership with 247Ergo, an ergonomics specialty firm. Purpose of the partnership is ... the companies undertake could improve worker mobility, functionality and fitness levels. , ...
Breaking Medicine News(10 mins):Health News:Sofia Fund Surpasses Investor Goals 2Health News:July is UV Awareness Month: Learn Top Tips from a Prominent Dermatologist this National UV Awareness Month 2Health News:July is UV Awareness Month: Learn Top Tips from a Prominent Dermatologist this National UV Awareness Month 3Health News:Stealth Therapeutics Inc. Enrolls First Patients in a Clinical Performance Study for the Invisiport Product Line 2Health News:Stealth Therapeutics Inc. Enrolls First Patients in a Clinical Performance Study for the Invisiport Product Line 3Health News:Author Warns Public to Prepare for Imminent Environmental Disaster 2Health News:HealthPostures and 247Ergo Partnership Strengthens America's Wellness 2Health News:HealthPostures and 247Ergo Partnership Strengthens America's Wellness 3
... February 2009 Nearly half of patients with heart ... of cognitive functioning, reports a new study published by ... Cardiac Failure ( http://www.elsevier.com/locate/cardfail ). , Memory ... factor to consider in planning medical care for patients ...
... 5 Medifast, Inc. (NYSE: MED ... that Executive Chairman of the Board Bradley MacDonald ... Founded in 1992, Leadership Maryland is an independent, ... from the public and private sectors about the ...
... recently debuted to help service providers and medical practices strengthen their ... practices the edge needed to build their businesses. , ... ... providers and physicians in search of a customized approach to ...
... MinuteClinic, the pioneer and largest provider of retail ... it has become a participating provider in the ... Carolina.BlueCross, Preferred Blue and Medicare Advantage members now ... located in the Columbia and Greenville markets. BlueCross ...
... half wait at least a month before seeking help, ... Most breast cancers in Hispanic women are detected by ... population, a new study shows. , What,s troubling, however, ... an abnormality during a self-exam waited at least a ...
... high standards set by independent scientific association to ... According to a new set of guidelines ... Probiotics and Prebiotics (ISAPP) there are five key ... probiotic product -- strain specificity, clinical proof, packaging, ...
Cached Medicine News:Health News:Heart failure linked to cognitive impairment 2Health News:Executive Chairman of Medifast Bradley MacDonald Selected to Participate in Leadership Maryland 2Health News:Executive Chairman of Medifast Bradley MacDonald Selected to Participate in Leadership Maryland 3Health News:Medical Marketing Firm Builds Service Provider and Medical Practice Bottom Lines 2Health News:Medical Marketing Firm Builds Service Provider and Medical Practice Bottom Lines 3Health News:MinuteClinic Becomes Participating Provider With Preferred Blue Network of BlueCross BlueShield of South Carolina 2Health News:Two-Thirds of Hispanic Women Discover Breast Cancer Themselves 2Health News:Align(R) Daily Probiotic Supplement Meets New Consumer Guidelines 2Health News:Align(R) Daily Probiotic Supplement Meets New Consumer Guidelines 3Health News:Align(R) Daily Probiotic Supplement Meets New Consumer Guidelines 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: