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Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data,on Molecular Imaging Pharmaceutical for Prostate Cancer

e paper, "Molecular Targeting of Prostate Cancer with Small Molecular Inhibitors of Prostate Specific Membrane Antigen," with the 2007 Berson-Yalow Award. The award, which is given to the investigator who has submitted the most original scientific abstracts and made the most significant contributions to basic or clinical radioassay, was presented to John Joyal, Ph.D., Director, Biology at Molecular Insight and presenting author of the paper. SNM honored Molecular Insight with a commemorative plaque in a presentation ceremony on June 3rd.

Dr. Babich commented, "Molecular Insight is extremely honored to receive the prestigious Berson-Yalow Award. It testifies to the scientific leadership of Molecular Insight and underscores the company's ability to use our screening and radiolabeling expertise to design, synthesize and evaluate small molecules as potential molecular imaging pharmaceuticals; in this case, for the detection, staging and prognosis of prostate cancer."

In data presented at the meeting, the researchers demonstrated that MIP-1072 binds with high affinity to the PSMA protein on the cancer cell surface and that it is internalized into prostate cancer cells. In vivo, human prostate cancer xenograft studies demonstrated that MIP-1072 was present in high concentration in tissues expressing PSMA, but not in tissues where it is absent. The studies also demonstrated a favorable imaging window of two to six hours retention post-injection. Authors on the study are K.P. Maresca, Ph.D.; S.M. Hillier, Ph.D.; F.J. Femia, Ph.D.; C. Barone, J.L. Joyal, Ph.D.; C. N. Zimmerman, Ph.D.; J.A. Barrett, Ph.D.; W.C. Eckelman, Ph.D.; and J.W. Babich, Ph.D., of Molecular Insight; and C.A. Foss, Ph.D.; and M.G. Pomper, M.D., Ph.D., of Johns Hopkins University.

About the Berson-Yalow Award

The Berson-Yalow Award, for outstanding scientific abstract in nuclear medicine radiopharma-ceutical sciences, commemorates the work of Rosalyn S. Yalow, Ph.D., and the l
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