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Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data,on Molecular Imaging Pharmaceutical for Prostate Cancer

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 4, 2007 - Researchers at Molecular Insight Pharmaceuticals today announced the presentation of preclinical data on MIP-1072, a radiolabeled, small molecule molecular imaging pharmaceutical in development for diagnosis and staging of prostate cancer at the 54th annual meeting of the Society of Nuclear Medicine (SNM) in Washington, D.C. MIP-1072 is one of two development candidates for prostate cancer diagnosis that Molecular Insight plans to advance into exploratory human studies in the first half of next year. It is designed to target prostate specific membrane antigen (PSMA), a protein highly expressed by prostate tumor cells. The presentation is one of four on the company's products and technologies to be presented at the meeting.

"Accurate diagnosis and the ability to properly assess the true extent and aggressiveness of prostate cancer are fundamental to appropriate therapeutic management of the disease," said John W. Babich, Ph.D., President and Chief Scientific Officer of Molecular Insight and an author on the study. "Treatment of prostate cancer is challenging, and the effects of treatment may substantially impact a man's quality of life for many years. Therefore, it is crucial that those faced with difficult clinical questions make the right decisions."

"We believe PSMA represents an exceptional target for the molecular imaging of prostate cancer due to its near 100% expression in the disease. Our preclinical studies suggest that MIP-1072 can identify the presence of prostate tumors specifically and non-invasively by targeting PSMA expression on prostate cancer cells. A PSMA-targeted molecular imaging pharmaceutical such as MIP-1072 may lead to improvements in the staging of prostate cancer patients and may represent a unique opportunity to risk stratify patients and monitor response to therapy," he added.

The Society of Nuclear Medicine recognized th
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