Navigation Links
Mild Asthma, a Revolutionary Therapy from Italian Research

Published by the New England Journal of Medicine the B.E.S.T study conducted in Italy


Prof. Fabbri: “Daily drug useless for mild persistent types affecting over one million 200 thousand people”. Chiesi’s commitment to pneumological research

MILAN, Italy, 29th May 2007 – Farewell to the daily dose of cortisone necessary for the control of mild persistent asthma: an Italian study has demonstrated that successful management of the disease is possible in the early stages without the need for daily maintenance therapy. A new “when needed” approach that may significantly improve the quality of life for one million 200 thousand Italians suffering from this disease. Amongst these sufferers there are also those suffering from allergic asthma, which is very common particularly at this time of year.

These are the results of a clinical study on BEST (BEclomethasone plus Salbutamol Treatment), published by the New England Journal of Medicine, one of the most prestigious international medical publications, sponsored by Chiesi Farmaceutici and the most important pneumological centres in Italy. “This is a revolutionary study – says research coordinator, Professor Leonardo Fabbri, Head of the Clinic for Respiratory Tract Diseases at the University of Modena and Reggio Emilia – as it questions a pivotal issue within the therapeutic programme for asthma in this group of patients. Our research has demonstrated that basic inhalant therapy with a preconstituted combination of a bronchodilator (salbutamol) and cortisone (beclometasone dipropionate), taken when symptoms first appear, allows clinical control similar to that provided by continuous daily inhalant therapy with cortisone plus bronchodilator when required, as recommended by current guidelines. Clinical research in Italy gains important international recogni tion through publication in the New England Medical Journal”.

BEST is a multi-centre study (involving 8 Italian and 14 European centres), which enrolled 500 patients, monitored for 6 months. “Only sufferers who are considered mild persistent asthmatics according to current criteria were selected – explains Professor Alberto Papi, Head of the Clinic for respiratory tract illness at the University of Ferrara and assistant co-ordinator of the study. 60% of those involved in the study were suffering from allergic asthma. These are individuals who are well for most of the time, and for whom it is extremely difficult to guarantee that continuous therapy is followed as set out by current guidelines”.

“For nearly thirty years, the Chiesi Group has continuously developed the combination therapy involving bronchodilators and corticosteroids – comments Dr. Paolo Chiesi, Vice President and Head of the Italian company’s Research and Development division – Over time this initial perception has become an increasingly evident rationale and has gained significance in important clinical trials, such as the BEST study”.

“On the basis of our daily experience, – explains Dr. Germano Bettoncelli, Director of the respiratory area for the Società Italiana di Medicina Generale (Italian Society for General Medicine) – we can confirm that, when symptoms develop, most of the patients affected by this form of asthma tend to use the bronchodilator alone when required, or resort to a “DIY” drug combination, behaviour which to date has been tolerated even if it is “unorthodox”. We are therefore most certainly interested in the fact that data in support of treatment to be used when required is now emerging with the preconstituted combination of the two drugs, as this is a less burdensome and demanding therapeutic strategy&rd quo;.

Of course, but what about the patient? “It is still very difficult to get across the concept that mild persistent asthma is a chronic disease, particularly in the early stages, when the person only experiences symptoms from time to time – says Dr. Filippo Tesi, President of Federasma, the Italian Asthma Patients’ Association . The management of asthma is however closely related to the patient’s quality of life. If the disease is not correctly managed, symptoms and attacks occur much more frequently. Some of the reasons why patients fail to stick to therapy include the complex nature and the frequency of the treatment, the administration of a number of drugs several times a day, the fear of side effects, even in the long-term, and a lack of faith in the drugs. One approach that does however allow the disease to be managed more simply, would also appear to be an excellent solution for encouraging patients to stick to the treatment”.

Press Office

Intermedia HYPERLINK ""


Related medicine technology :

1. Accentia Biopharmaceuticals Scientific Presentations Demonstrate Increasing Acceptance of Fungal Etiology of Chronic Sinusitis at the Annual Meeting of the American Academy of Allergy, Asthma, and Immunology
2. Revolutionary Immunologic Data Explains Function of Diamyd Diabetes Vaccine
3. Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.
4. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
5. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
6. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
7. Response Genetics Announces Publication of a Phase III Clinical Trial Demonstrating That Low Levels of ERCC-1 Help to Predict Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer
8. New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV
9. Lexicon Develops Antibodies That Lower Triglycerides and Cholesterol as Potential New Therapy for Heart Disease
10. Studies of Drug Resistance May Lead to Individual Therapy for Rare Cancers
11. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
Post Your Comments:
(Date:11/26/2015)... 3D bioprinting market is expected ... new report by Grand View Research Inc. Rising prevalence of ... kidney transplantation is expected to boost the market growth, as ... transplantation. --> 3D bioprinting market is expected ... new report by Grand View Research Inc. Rising prevalence of ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... Global Cell Surface Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
(Date:11/26/2015)... Research and Markets ( ) has ... Market by Type (Dressings, Therapy Devices, Active Wound Care), ... Facility), and Geography - Global Forecast to 2020" ... --> The purpose of this report ... the global advanced wound care market. It involves deep ...
Breaking Medicine Technology:
(Date:11/25/2015)... ... 2015 , ... The holiday season is jam-packed with family ... of attendees is of the utmost importance. Whether you are cooking at home ... recipes a try this holiday season. , Turkey Croquettes ,     Ingredients: ...
(Date:11/25/2015)... ... 2015 , ... Ministers, senior government and UN agencies, representatives ... of Excellence, and public R&D institutions, civil societies and other partners gathered today ... African Network for Drugs and Diagnostics Innovation, ANDI, Stakeholders Meeting. The three- day ...
(Date:11/25/2015)... ... 25, 2015 , ... Dental professionals who would like to become more proficient ... attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will be held ... the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio are proud ...
(Date:11/25/2015)... ... November 25, 2015 , ... Smiles by Stevens ... Bruxism, and moderate facial wrinkling. While many patients are aware of the benefits of ... success Botox® delivers to those suffering with discomfort, soreness, and pain as a result ...
(Date:11/25/2015)... , ... November 25, 2015 , ... “While riding the ... inventor, from Bronx, N.Y. “I thought there had to be a convenient and comfortable ... PROTECTOR. , The PROTECTOR enables disabled individuals to safely travel during cold or inclement ...
Breaking Medicine News(10 mins):