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Micromet and MedImmune Present Data From Preclinical Study of New,BiTE Molecule Targeting CEA

GAITHERSBURG, Md. and CARLSBAD, Calif., April 18, 2007 /PRNewswire-FirstCall/ -- Micromet, Inc. and MedImmune, Inc. today announced data from a preclinical study in which BiTE(R) molecules targeting carcinoembryonal antigen (CEA) were shown to prevent subcutaneous tumor growth and formation of lung metastases. An established marker for tumor progression, CEA is frequently expressed on breast, colon and other human carcinomas. These data, presented yesterday in a poster session at the 2007 Annual Meeting of the American Association for Cancer Research (AACR), augment a growing body of preclinical and clinical research about the potential anti-cancer activity of BiTE molecules.

BiTE molecules represent a novel class of drugs that function as bi- specific T-cell engagers. They are unique in their ability to enable the body's killer T cells to recognize and attack tumor and target cells, leaving normal cells unharmed. In addition to demonstrating in vitro and in vivo anti- tumor activity, certain CEA-specific BiTE molecules also showed resistance to inhibition by soluble CEA. Because a soluble form of CEA is released from the surface of normal and tumor cells into the bloodstream, BiTE molecules targeting the antigen must not be inhibited by soluble CEA.

"In a joint effort, researchers at Micromet and MedImmune have developed CEA BiTE molecules that appear to be highly potent and to ignore levels of soluble CEA present in cancer patients while continuing to destroy tumor cells," said Patrick Baeuerle, Ph.D., Chief Scientific Officer at Micromet.

CEA is the second target in the research collaboration between Micromet and MedImmune against which new BiTE molecules were successfully generated and tested. The first target is the tyrosine kinase receptor EphA2, which is frequently overexpressed on a wide variety of solid tumors. Research published April 15, 2007 in Cancer Research demonstrated that
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