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Microbia Announces Positive Phase 2 Results for Its Investigational,Compound Linaclotide

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"We are pleased that these results complement our previous study with linaclotide in patients suffering from chronic constipation," said Mark Currie, Ph.D., Microbia's senior vice president of research and development. "These data greatly expand our understanding of the potential beneficial actions of linaclotide in patients with lower bowel dysfunction and provide an impetus to advance this agent in later stage clinical development."

About Linaclotide

Linaclotide is a first-in-class compound currently being tested for the treatment of IBS-C, CC and other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing linaclotide was shown to increase fluid secretion into the intestine, accelerate intestinal transit, and decrease visceral pain. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. In Phase 1 testing linaclotide was well tolerated and was not detected in the systemic circulation of healthy subjects. Linaclotide is currently being studied in a pair of Phase 2 dose- ranging trials for IBS-C and CC.

About Irritable Bowel Syndrome (IBS)

One out of six adults in developed countries suffers from IBS, a chronic condition marked by abdominal pain and disturbed bowel function. Patients with IBS often have altered patterns of gastrointestinal motility which contribute to symptoms. Colonic transit that is too rapid results in diarrhea, while delayed colonic transit results in constipation. IBS accounts for 12% of adult visits to primary care physicians and is the most common disorder diagnosed by gastroenterologists. Health care costs associated with IBS exceed $25 billion annually. IBS patients fall into three subgroups-constipation-predominant (IBS-C), diarrhea-predominant (IBS-D), and alternating (IBS-A)-and 30% to 40% of these patients suffer from IBS-C.
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