Navigation Links
Metabasis Therapeutics Presents Results of Preclinical Studies for,MB07811, Its Novel Product Candidate for the Treatment of,Hyperlipidemia, at the Endocrine Society's Annual Meeting

miting cardiac effects as well as effects on the thyroid hormone axis, muscle metabolism and bone turnover. Metabasis believes that the combination of a TR beta-selective receptor agonist and liver-targeting could harness the efficacy of the approach by avoiding extra-hepatic activation of TR alpha receptors and TR beta receptors that may lead to these therapy-limiting side effects.

"MB07811 is the first of a novel class of product candidates discovered by Metabasis designed to lower serum cholesterol, serum triglycerides and liver fat," stated Dr. Mark Erion, executive vice president of research and development and chief scientific officer of Metabasis. "MB07811 combines a novel agonist selective for the beta isoform of the thyroid hormone receptor with our proprietary, liver-targeting HepDirect(R) prodrug technology. The combination of beta receptor selectivity, liver-targeting and other structural characteristics that limit extra-hepatic activity provides a product candidate that exhibits significant efficacy while avoiding side effects commonly associated with activation of thyroid hormone receptors outside the liver. If we can demonstrate these characteristics in humans, it should provide important evidence that MB07811 and this class of drugs could represent an exciting new therapeutic approach for treating hyperlipidemia."

Dr. Paul Laikind, president and chief executive officer of Metabasis, said, "The results of these studies and others supported the decision to initiate the clinical development of MB07811. The first human clinical study was successfully completed late last year and we expect to start a Phase 1b multiple dose study in healthy volunteers with moderately elevated LDL cholesterol by the end of this quarter."

About Metabasis (www.mbasis.com):

Metabasis Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of novel drugs to address some of the world's most widespread an
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Metabasis to Present at C.E. Unterberg, Towbin Emerging Growth Conference and Attend Pacific Growth Equities Conference
2. Metabasis Therapeutics to Present Poster at American Association for Cancer Research
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
5. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
6. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
7. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
8. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
9. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
10. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
11. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
Post Your Comments:
(Date:8/28/2015)...  Today, in final recognition of the Centers for ... 1-800 Contacts is sharing how to keep lens cases ... who do not properly care for their lens cases ... Most contact lens wearers understand the importance ... case is sometimes overlooked.  When proper steps to clean ...
(Date:8/28/2015)... -- Research and Markets ( ... "Investigation Report on China,s Latanoprost Market, 2010-2019" ... by Pharmacia & Upjohn in 1995, latanoprost is ... intraocular pressure. As the first pressure- lowering prostaglandin ... of Xalatan) entered China ...
(Date:8/28/2015)... Perrigo Company plc ("Perrigo") (NYSE: PRGO ; TASE) ... MYL ) shareholder vote regarding its planned unsolicited offer ... offer to Perrigo shareholders have always been, and will ... of the value available to Perrigo shareholders, and do ... allowed its shareholders to consider," said Joseph C. ...
Breaking Medicine Technology:1-800 Contacts Shares Tips on How to Clean Lens Cases 2China Latanoprost Market Investigation Report 2015-2019 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5
... Therapeutics, Inc. (NASDAQ: HALO ) today reported ... (Logo:  http://photos.prnewswire.com/prnh/20100302/LA63139LOGO ) "We ... the European regulatory filing of the subcutaneous Herceptin program ... President and Chief Executive Officer, Halozyme. "Despite the HyQ ...
... be the largest payment ever enforced involving off-label misuse ... Eisenhofer , working with the U.S. Justice Department and ... settlement with Abbott Laboratories over its illegal marketing of ... The settlement was reached between Abbott (NYSE: ...
Cached Medicine Technology:Halozyme Reports First Quarter 2012 Financial Results 2Halozyme Reports First Quarter 2012 Financial Results 3Halozyme Reports First Quarter 2012 Financial Results 4Halozyme Reports First Quarter 2012 Financial Results 5Halozyme Reports First Quarter 2012 Financial Results 6Grant & Eisenhofer Represents Lead Whistleblower in Historic $1.6 Billion Settlement with Abbott Laboratories Over Off-Label Marketing of Antiepileptic Medication Depakote 2Grant & Eisenhofer Represents Lead Whistleblower in Historic $1.6 Billion Settlement with Abbott Laboratories Over Off-Label Marketing of Antiepileptic Medication Depakote 3Grant & Eisenhofer Represents Lead Whistleblower in Historic $1.6 Billion Settlement with Abbott Laboratories Over Off-Label Marketing of Antiepileptic Medication Depakote 4
(Date:8/28/2015)... ... , ... On May 30th, 2015, Best Drug Rehabilitation, a results-based substance abuse ... Mission” benefit concert in Mendon, IL. Held in the Show Barn at the Adams ... education programs in the underfunded local school districts of Mendon at neighboring Quincy, IL. ...
(Date:8/28/2015)... ... August 28, 2015 , ... “ Frequentz ” was ... the latest and coolest applications on the market for iOS, Android, and Windows. Joe ... with viewers how this software allows businesses to track product movement from beginning to ...
(Date:8/28/2015)... ... August 28, 2015 , ... Medical Solutions, one of the ... Places to Work in Healthcare by Modern Healthcare and will be honored at ... in its eighth year, the Best Places to Work in Healthcare program recognizes outstanding ...
(Date:8/28/2015)... ... ... Gregory K. Toumayan, D.C., Q.M.E., is now treating patients with back pain and associated ... pain, stiffness, muscle spasms, and numbness. , Dr. Toumayan received his Bachelor of ... earn his title of Doctor of Chiropractic from the Palmer College of Chiropractic and ...
(Date:8/28/2015)... ... 2015 , ... Northridge dentists Dr. Elyson and Dr. Assili are ... can currently receive a one hour treatment of this teeth whitening option. Zoom ... number of unique features that can turn teeth up to nine shades whiter. Effective ...
Breaking Medicine News(10 mins):Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2Health News:Track Product Movement from Beginning to End with Frequentz 2Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 2Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 3Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3Health News:Northridge Dentists Dr. Elyson and Dr. Assili Now Offer a Special Promotion on Zoom Teeth Whitening 2
... , MONDAY, April 9 (HealthDay News) -- People who stay ... because they feel they don,t have a choice are at ... "When employees stay with their organization because they feel ... to experience emotional exhaustion. This feeling, in turn, may lead ...
... Breast Cancer Genome Guided Therapy Study (BEAUTY Project) will ... on their individual genomes and the genomes of their ... sequences: one from the patients, healthy cells before treatment, ... one after. Patients will be paired with mouse "avatars" ...
... News) -- Not only do regular dental exams help keep ... cancer, the Academy of General Dentistry says. As part ... that people get a dental exam from a general dentist ... dentist, ask about an oral cancer screening," academy spokesperson Dr. ...
... more pronounced in individuals with an unacknowledged attraction to ... parents who forbade such desires, a series of psychology ... document the role that both parenting and sexual orientation ... of homosexuals, including self-reported homophobic attitudes, discriminatory bias, implicit ...
... receiving in-patient rehabilitation are more likely to land back ... functioning poorly, show signs of depression and lack social ... Medical Branch (UTMB) at Galveston. Hospital readmission for older ... $18 billion annually. , Among the first of ...
... News) -- Surgery for esophageal cancer can result ... new study finds. Common complaints among patients ... surgery include breathlessness, fatigue, insomnia and eating problems, ... Sweden. Patients who experienced a serious complication after ...
Cached Medicine News:Health News:Mayo Clinic launches whole genome breast cancer study 2Health News:Mayo Clinic launches whole genome breast cancer study 3Health News:Dentists Play Key Role in Detecting Oral Cancer 2Health News:Is some homophobia self-phobia? 2Health News:Is some homophobia self-phobia? 3Health News:Is some homophobia self-phobia? 4Health News:Predictors identified for rehospitalization among post-acute stroke patients 2Health News:Predictors identified for rehospitalization among post-acute stroke patients 3Health News:Esophageal Cancer Surgery Can Leave Lingering Health Problems, Study Says 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: