Navigation Links
Merck's Investigational Migraine Treatment MK-0974 Significantly,Improved Migraine Pain on Several Efficacy Measures in a Phase II,Study

treatment effect of MK-0974 for each measure was significant compared to placebo (p<0.001), and included:

-- two-hour pain freedom (reduction to no pain): 45.2 percent for 300 mg, 24.3 percent for 400 mg and 32.1 percent for 600 mg of MK-0974 respectively; 33.4 percent for rizatriptan and 14.3 percent for placebo;

-- 24-hour sustained pain-relief (defined as those with pain relief at two hours with no recurrence of headache and no use of optional second dose or rescue medication during the 2-24 hour period): 52.6 percent for 300 mg, 37.8 percent for 400 mg, 52.5 percent for 600 mg of MK-0974 respectively; 35.3 percent for rizatriptan and 23.5 percent for placebo; and

-- 24-hour sustained pain-freedom (defined as those with no pain at two hours who remain free of pain during the 2-24 hour period with no use of optional second dose or rescue medication): 39.6 percent for 300 mg, 22.0 percent for 400 mg, 32.0 percent for 600 mg of MK-0974 respectively; 18.4 percent for rizatriptan and 11.0 percent for placebo.

In addition to the measure of migraine pain, MK-0974 provided relief of migraine-associated symptoms, including nausea and sensitivity to light and sound, and improved functional disability two hours post dose, as well as reduced patients' need for rescue medication. However, the study was not powered to evaluate a statistical response to these measures.

In the study, treatment with MK-0974 was generally well tolerated with no reports of serious adverse events. The most common adverse experiences occurring in patients treated with MK-0974 were nausea, dizziness and somnolence. There also were no increases in adverse events associated with increasing doses studied.

"These results provide additional evidence of the potential benefit of CGRP receptor antagonists as a new and promising class of migraine therapies," said Alan Rapoport, M.D., clinical professor of Neurology at the David Geffen School of Medicine at UCLA in Los
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. New England Journal of Medicine Publishes New Data on Gardasil, Mercks Cervical Cancer Vaccine
2. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
3. An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes
4. Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes
5. Investigational Study Demonstrated a Re-Establishment of Clinical Improvement with Orencia (Abatacept) in Children with Juvenile Idiopathic Arthritis upon Re-Introduction of Therapy
6. Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
7. Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)
8. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
9. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
10. Investigational Cancer Drug Pertuzumab Shows Promising Results in Advanced Breast Cancer When Combined with Herceptin
11. Shire Announces Positive Results of Studies With Guanfacine Extended Release, An Investigational Nonstimulant Medication Filed for the Treatment of ADHD in Children and Adolescents
Post Your Comments:
(Date:9/16/2014)... 2014  DNAtrix, Inc., experts in oncolytic virus ... treated with the company,s lead product, DNX-2401, a ... randomized, multicenter, open-label Phase Ib study for patients ... with leading neurosurgeons and neuro-oncologists in the US, ... randomized Phase Ib study of DNX-2401 at Moffitt ...
(Date:9/16/2014)... 16, 2014  Eli Lilly and Company (NYSE: ... an agreement to co-develop and commercialize AZD3293, an ... in development as a potential treatment for Alzheimer,s ... is characterized by the accumulation of amyloid plaque ... with the development of beta-amyloid. Inhibiting BACE is ...
(Date:9/15/2014)... Sept. 16, 2014  Bayer HealthCare and Orion ... Finland , have begun to enroll ... an investigational oral androgen receptor inhibitor in clinical ... men with castration-resistant prostate cancer who have rising ... metastases. The trial is designed to determine the ...
Breaking Medicine Technology:DNAtrix Announces Treatment Of First Patient With DNX-2401 In Recurrent Glioblastoma Trial 2Lilly and AstraZeneca announce alliance to co-develop potential treatment for Alzheimer's disease 2Lilly and AstraZeneca announce alliance to co-develop potential treatment for Alzheimer's disease 3Lilly and AstraZeneca announce alliance to co-develop potential treatment for Alzheimer's disease 4Bayer and Orion Initiate Phase III Trial of ODM-201 in Men with High-Risk Non-Metastatic Castration-Resistant Prostate Cancer 2Bayer and Orion Initiate Phase III Trial of ODM-201 in Men with High-Risk Non-Metastatic Castration-Resistant Prostate Cancer 3
... Biopharmaceuticals, Inc. (Nasdaq: KERX ) today announced that ... at the Lazard Capital Markets 8th Annual Healthcare Conference, being ... Bentsur,s presentation is scheduled to take place on Wednesday, November ... audio webcast of Mr. Bentsur,s presentation will be accessible from ...
... 2011 Booth # 407 at The American ... NxStage® Medical, Inc. (Nasdaq: NXTM ), ... announced that its Medisystems division has won a ... Solution to Atlantic Dialysis Management Services centers. ...
Cached Medicine Technology:Keryx Biopharmaceuticals to Present at Lazard Capital Markets 8th Annual Healthcare Conference 2NxStage Awarded Multi-Year Contract to Supply Atlantic Dialysis Management Services with Vasc-Alert Access Surveillance Solution 2NxStage Awarded Multi-Year Contract to Supply Atlantic Dialysis Management Services with Vasc-Alert Access Surveillance Solution 3
(Date:9/16/2014)... NEW YORK, NY (September 16, 2014) The ... received the 2014 Higher Education Excellence in Diversity ... oldest and largest diversity-focused publication in higher education. ... national honor recognizing U.S. colleges and universities that ... will be featured along with 82 other recipients ...
(Date:9/16/2014)... Orange, NJ. September 16, 2014. Kessler Foundation researchers ... slowed processing speed in the executive deficits found ... slowed processing speed account for executive deficits in ... neuroimaging," was published online ahead of print on ... The authors are Victoria Leavitt, PhD, of ...
(Date:9/16/2014)... judges are the unwitting focus of some of Australia,s ... to improve their performance in competition, thanks to a ... Dr Daniel Greenwood, from QUT,s Institute of Health and ... Sport Centre of Excellence for Applied Sport Science Research, ... such as cricket, long jump, triple jump and pole ...
(Date:9/16/2014)... San Francisco, September 15, 2014 For patients with ... and stereotactic ablative radiation (SABR) may be a ... surgery that may not otherwise be an option, ... Society for Radiation Oncology,s (ASTRO,s) 56th Annual Meeting. ... for individuals with pancreatic ductal adenocarcinoma (PDA), the ...
(Date:9/16/2014)... be presented at the ESMO 2014 Congress will be ... (CEST) to give you a first glimpse of what ... under the leading theme Precision Medicine in Cancer Care. ... therapy is now possible for an increasing number of ... towards a common goal --improved patient outcomes. This is ...
Breaking Medicine News(10 mins):Health News:Columbia University College of Dental Medicine receives diversity award 2Health News:Columbia University College of Dental Medicine receives diversity award 3Health News:Columbia University College of Dental Medicine receives diversity award 4Health News:Getting the jump on competitors: QUT study 2Health News:Chemotherapy and SABR consecutively may be promising treatment option for advanced pancreatic cancer 2Health News:Chemotherapy and SABR consecutively may be promising treatment option for advanced pancreatic cancer 3Health News:Chemotherapy and SABR consecutively may be promising treatment option for advanced pancreatic cancer 4Health News:ESMO 2014 Congress Preview 2
... School of Medicine has helped confirm the reliability of ... individual's genetic makeup. ,The Stanford group was ... the genetic test can identify patients who are at ... infection. That means high-risk patients could be directed toward ...
... A report released by the Australian Institute of Health ... in Queensland. Nearly 20 to 50% of the population ... to be relying on anti-depressants heavily. ... affair in Queensland where nearly 11,500 prescriptions for anti ...
... today has become the number one killer. More so, related ... occupational Hazard// with millions of people running the risk of ... fibers and second hand smoker are the major causes of ... from exposure to benzene from the dye, drugs, pesticides and ...
... the world. There is also a rise of alcohol abuse ... women says that in women cognitive problems develop faster in ... subject to physical changes in the brain more rapidly than ... at the research institute RTI at the university in Baltimore ...
... Institute of Medicine released a report recommending nutrition ... school environment, such as a la carte cafeteria ... Dairy Council (NDC) applauds the overall recommendations outlined ... nonfat and low-fat dairy products, fruits, vegetables and ...
... An international research team, led by investigators from the ... Institute (DFCI), has found// a new way that some ... drugs like Iressa and Tarceva. Their report, which will ... online release, describes a totally new resistance mechanism that ...
Cached Medicine News:Health News:New Test Helps Identify Hepatitis C Patients at High Risk of Developing Cirrhosis 2Health News:New Test Helps Identify Hepatitis C Patients at High Risk of Developing Cirrhosis 3Health News:Today Cancer is the Deadliest Killer 2Health News:Alcoholism Develops Cognitive Problems in Women 2Health News:National Academy of Sciences' Institute of Medicine Report Calls for More Dairy Foods at School 2Health News:New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs 2Health News:New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs 3
... Innovations' Instrument Manager (IM) is an instrument ... system that enables laboratories to work more ... as a data management solution that stands ... information system, filling those important gaps in ...
... These color vision tests have been designed ... the type and estimating the grade of ... measure Red, Green, Blue, Yellow. They provide ... deficiencies. Screening is accomplished using the initial ...
... sets are designed to indicate color deficiency ... is used to separate Medium and Strong ... test is much more difficult and is ... Both of these tests provide basic ...
Single Use Loading Units with Titanium Staplers for use with MULTIFIRE ENDO TA™ 30 12 mm (Single Use Staplers with Titanium Staplers)....
Medicine Products: