( posomeVaccine) in the treatment of non...)Merck at ASCO 2007: Encouraging Results in Progression-Free,Survival in Patients With Aggressive Brain Tumors (glioblastoma),Using Cilengitide in Phase I/IIa Study,Health

posome Vaccine) in the treatment of non-small cell lung cancer. The vaccine was granted fast-track status in September 2004 by the FDA. Merck obtained the exclusive worldwide licensing rights from Biomira Inc. of Edmonton, Alberta, Canada, with the exception of Canada where the companies share rights.

References:
1. Stupp et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352:987-996.
2. Hegi et al., MGMT gene silencing and benefit from temozolomide in glioblastoma. NEJM 2005; 352(10):997-1003.
3. Max Parkin et al. Global Cancer Statistics, 2002. CA Cancer J Clin 2005; 55:74-108.
4. Levin et al. Neoplasms of the central nervous system. In DeVita VT Jr, Hellman S, Rosenberg SA, eds: Cancer: Principles and Practice of Oncology. 6th ed. Philadelphia, Pa: Lipponcott Williams & Wilkens 2001; 2100-2160.
5. Nabors et al. Phase I and Correlative Biology Study of Cilengitide in Patients with Recurrent Malignant Glioma. J Clin Oncol 2007; 25: 1651-1657.

Merck is a global pharmaceutical and chemical company with sales of EUR 6.3 billion in 2006, a history that began in 1668, and a future shaped by 35,091 employees in 62 countries. Its success is characterized by innovations from entrepreneurial employees. Merck's operating activities come under the umbrella of Merck KGaA, in which the Merck family holds an approximately 70% interest and free shareholders own the remaining approximately 30%. In 1917 the U.S. subsidiary Merck & Co. was expropriated and has been an independent company ever since.

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