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MedImmune and Micromet Publish Data on Novel Anti-Cancer BiTE,Molecule

e the tyrosine kinase was sequestered within intercellular boundaries.

Under the terms of the companies' BiTE research collaboration agreement, MedImmune holds the rights to bscEphA2xCD3. Micromet may receive milestone and royalty payments based on the successful development and commercialization of the compound and has the option to co-promote the product in Europe. Under a separate agreement, Micromet and MedImmune collaborate on the development of MT103/MEDI-538, a BiTE molecule being developed to treat B-cell non-Hodgkins lymphoma.

"As a result of our collaboration around this novel technology platform, MedImmune's portfolio of potential cancer treatments has expanded to include several BiTE molecules targeting a range of tumor types," said Peter Kiener, MedImmune's Senior Vice President, Research. "As a company committed to developing innovative therapies for patients with cancer, we are encouraged by the broad therapeutic potential and promising biologic activity that these molecules have shown to date."

About BiTE(R) Molecules:

BiTE(R) molecules are a novel class of antibody derivatives with the potential to selectively direct and activate an individual's cytotoxic T cells, the body's most potent killer cells, to act against cancer cells. MT103/MEDI-538, a BiTE specific for the B cell antigen CD19, provided clinical proof-of-concept for the BiTE platform technology, as presented at the last meeting of the American Society for Hematology. In an ongoing phase 1 study, MT103/MEDI-538 has shown potent elimination of tumor target cells in peripheral blood, bone marrow, lymph nodes and spleen of therapy-refractory non-Hodgkins lymphoma patients.

About MedImmune, Inc.

MedImmune strives to provide better medicines to patients, new medical options for physicians, rewarding careers to employees, and increased value to shareholders. Dedicated to advancing science and medicine to help people live better lives, the company is focu
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