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MedImmune Highlights Advances in Inflammatory Disease Pipeline With,Series of Data Presentations

9's role in mast cell regulation, airway remodeling, and other functions involved in the onset of asthma symptoms, we believe these preclinical data provide further support for IL-9 inhibition as a potential therapeutic approach to treating patients with moderate to severe asthma."

Preclinical data presented at ATS suggest that IL-9 plays a critical and unique role in regulating mast cells, which are centrally important in allergic inflammation of the airways. Additional presented data provide insight to IL-9's role in allergen-induced airway remodeling, a process involving structural changes that occur in conjunction with, or as a result of, chronic airway inflammation such as that seen in patients with asthma.

    Data presented at ATS include:

    -- "Allergic Sensitization and Airway Inflammation in Response to Low Dose

       House Dust Mite Exposure After Influenza A Infection" (Publication Page

       A211, Poster Board #C61, presented in a poster session titled,

       "Inflammation and Host Defense," on Sunday, May 20 at 8:15 a.m.)

    -- "Proinflammatory Effects of Type 1 Interferon Exacerbate Primary RSV

       Disease in Susceptible NAB Mice" (Publication Page A210, Poster Board

       #C56, presented in a poster session titled, "Inflammation and Host

       Defense," on Sunday, May 20 at 8:15 a.m.)

    -- "Chitinase-Like Protein BRP-39 Mediates IL-13 Induced Airway

       Hyperresponsiveness (Publication Page A 253, Poster Board #508,

       presented in a poster session titled, "Mechanisms of Allergic Lung

       Inflammation, on Sunday, May 20 at 1:30 p.m.)

    -- "First In-Human Use of MEDI-528, a Monoclonal Antibody Against

       Interleukin-9" (Publication Page A483, Poster Board #F34, presented in

       a poster session titled, "Biologically Based Therapies for Asthma," on

       Monday, May 21 at 8:15 a.m.)

    -- "Distribution and Characterization of Lung Mast Cell Subtypes in COPD"

       (Publication Page A
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