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MaxCyte and Medinet to Present at the 13th Annual Meeting of the,International Society for Cellular Therapy (ISCT) in Sydney,,Australia

"Electroloading of mature dendritic cells with tumor lysate triggers robust antigen-specific CTL response"

GAITHERSBURG, Md., and YOKOHAMA, Japan, June 22, 2007 /PRNewswire/ -- MaxCyte, Inc. and Medinet Co., Ltd. announce a joint poster presentation at the 13th Annual Meeting of the International Society for Cellular Therapy. The meeting is being held June 24-27, 2007 in Sydney, Australia.

The presentation is entitled "Electroloading of mature dendritic cells with tumor lysate triggers robust antigen-specific CTL response" and will discuss the findings of a study that combined MaxCyte's technologies and Medinet's novel immuno-cell therapy technologies to produce more potent cancer vaccines. The session is scheduled for Monday, June 25 from 6:30-10:30 p.m.

The study was performed under a collaboration agreement in which MaxCyte optimized its proprietary cell loading technology for the development of Medinet's novel cancer immuno-cell therapy service for implementation in a closed-system, cGMP manufacturing process at Medinet's cell processing centers in Japan.

The presentation will discuss the development of a robust, scalable, cGMP compliant manufacturing process and the resulting production of dendritic cell (DC) vaccines with enhanced potency as demonstrated by higher antigen-specific T cell stimulation compared to current manufacturing processes. Final immunotherapeutic product exhibited high (>95%) cell viability and purity and showed characteristic DC immunophenotype as detected by increased expression of HLA class I, HLA class II, and co-stimulatory molecules. Compared with current manufacturing processes, this engineered DC product required less antigen but achieved substantially higher antigen loading per cell. The engineered DC vaccine elicited increased frequency of antigenpeptide-specific T cells in a 7 day in vitro stimulated culture, in direct head-to-head comparison with curre
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